Is target-based drug discovery efficient? Discovery and “off-target” mechanisms of all drugs

A Sadri - Journal of medicinal chemistry, 2023 - ACS Publications
Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

[HTML][HTML] Moist convection in the giant planet atmospheres

C Palotai, S Brueshaber, R Sankar, K Sayanagi - Remote Sensing, 2022 - mdpi.com
The outer planets of our Solar System display a myriad of interesting cloud features, of
different colors and sizes. The differences between the types of observed clouds suggest a …

Stratospheric planetary flows from the perspective of the Euler equation on a rotating sphere

A Constantin, P Germain - Archive for Rational Mechanics and Analysis, 2022 - Springer
This article is devoted to stationary solutions of Euler's equation on a rotating sphere, and to
their relevance to the dynamics of stratospheric flows in the atmosphere of the outer planets …

[HTML][HTML] Multistability and Rare Spontaneous Transitions in Barotropic β -Plane Turbulence

E Simonnet, J Rolland… - Journal of the Atmospheric …, 2021 - journals.ametsoc.org
We demonstrate that turbulent zonal jets, analogous to Jovian ones, which are quasi
stationary, are actually metastable. After extremely long times, they randomly switch to new …

Direct driving of simulated planetary jets by upscale energy transfer

VGA Böning, P Wulff, W Dietrich, J Wicht… - Astronomy & …, 2023 - aanda.org
Context. The precise mechanism that forms jets and large-scale vortices on the giant planets
is unknown. An inverse cascade has been suggested by several studies. Alternatively …

Near-cancellation of up-and down-gradient momentum transport in forced magnetized shear-flow turbulence

B Tripathi, AE Fraser, PW Terry, EG Zweibel… - Physics of …, 2022 - pubs.aip.org
Visco-resistive magnetohydrodynamic turbulence, driven by a two-dimensional unstable
shear layer that is maintained by an imposed body force, is examined by decomposing it into …

Global climate modeling of the Jupiter troposphere and effect of dry and moist convection on jets

A Boissinot, A Spiga, S Guerlet, S Cabanes, D Bardet - 2024 - aanda.org
ABSTRACT Aims. The atmosphere of Jupiter is characterized by banded jets, including an
equatorial super-rotating jet, by an intense moist convective activity, and by perturbations …

[PDF][PDF] Multistability and rare spontaneous transitions between climate and jet configurations in a barotropic model of the Jovian mid-latitude troposphere.'

E Simonnet, J Rolland, F Bouchet - arXiv preprint arXiv:2009.09913, 2020 - hal.science
We demonstrate that turbulent zonal jets, analogous to Jupiter ones, which are quasi-
stationary are actually metastable. After extremely long times they randomly switch to new …

[PDF][PDF] Biological sciences and physics unified: Internal evolution and urging the Second Scientific Revolution

A Sadri - sciences, 2021 - academia.edu
Why are there several sciences instead of only one? Are all sciences reducible to the “most
fundamental” one, physics? Should we try to do so now that we have the required tools …

Numerical Modelling of Zonal Winds on Gas Giants

PN Wulff - 2023 - ediss.uni-goettingen.de
The outer regions of both Jupiter and Saturn feature strong, alternately eastward and
westward zonal winds. Cloud tracking has yielded latitudinal profiles of these winds, which …