This paper addresses how long lifespan can be extended via multiple interventions, such as
dietary supplements [eg, curcumin, resveratrol, sulforaphane, complex phytochemical …

α-Synuclein (α-syn) is a presynaptic protein that regulates the release of neurotransmitters
from synaptic vesicles in the brain. α-Syn aggregates, including Lewy bodies, are features of …

Debilitating neuropsychiatric and neurodegenerative conditions are associated with
complex multifactorial pathophysiology. Their treatment strategies often only provide …

Dietary restriction (DR) interventions have demonstrated their efficacy in extending lifespan;
however, the association between lifespan extension and health span remains unclear. This …

Perfluorooctane sulfonate (PFOS) has been widely utilized in numerous industries. Due to
long environmental and biological half-lives, PFOS is a major public health concern …

The incidence and prevalence of age‐related neurodegenerative dementias have been
increasing. There is no curative therapy and conventional drug treatment can cause …

Bioactivity guided phytochemical investigation led to isolation of six undescribed furostanol
saponins, furoasparoside AF along with five known compounds, gallic acid, methyl gallate …

The principal bioactive ingredient of Asparagus racemosus is Shatavarin IV, a steroidal
saponin found in roots with a wide range of medicinal properties. A. racemosus roots are …

Parkinsonism is an age-associated neurodegenerative disorder characterized by
aggregation of α-synuclein (α-syn) protein in the substantia nigra region, degeneration of …

Abstract Mutations in Cu/Zn–superoxide dismutase 1 (SOD1) are linked to amyotrophic
lateral sclerosis (ALS). Using a line of ALS-related mutant human SOD1 (hSOD1) transgenic …