Preparing for the next viral threat with broad-spectrum antivirals
There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …
hundreds of viruses known to cause human disease and for the establishment of a …
Current thoughts on cellular functions of numb-associated kinases
C Huang, C Ji, J Wang - Molecular Biology Reports, 2023 - Springer
Members of the Numb-associated kinase family of serine/threonine kinases play an
essential role in many cellular processes, such as endocytosis, autophagy, dendrite …
essential role in many cellular processes, such as endocytosis, autophagy, dendrite …
Proteomic investigations of dengue virus infection: key discoveries over the last 10 years
S Hadpech, V Thongboonkerd - Expert Review of Proteomics, 2024 - Taylor & Francis
Introduction Dengue virus (DENV) infection remains one of the most significant infectious
diseases in humans. Several efforts have been made to address its molecular mechanisms …
diseases in humans. Several efforts have been made to address its molecular mechanisms …
[HTML][HTML] PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2
In search for broad-spectrum antivirals, we discovered a small molecule inhibitor, RMC-113,
that potently suppresses the replication of multiple RNA viruses including SARS-CoV-2 in …
that potently suppresses the replication of multiple RNA viruses including SARS-CoV-2 in …
Exosomes derived from umbilical cord mesenchymal stem cells ameliorate ischemic brain injury in mice by regulating AAK1 via miR-664a-5p
B Shen, N Liu, Y Dai - International Journal of Neuroscience, 2024 - Taylor & Francis
Objective To identify the molecular targets of MSC-derived exosomes in treating cerebral
ischemia and elucidate their therapeutic mechanisms. Methods We utilized a mouse model …
ischemia and elucidate their therapeutic mechanisms. Methods We utilized a mouse model …
核酸条形码技术: 扩展蛋白质⁃ 蛋白质相互作用检测通量的新方法.
李林鑫， 秦晓红， 米立志 - Chinese Journal of Biochemistry & …, 2024 - search.ebscohost.com
摘要蛋白质⁃ 蛋白质相互作用(protein⁃ protein interaction, PPI) 几乎参与了机体内所有重要的
生物学过程, 在细胞的基本生命过程中扮演了至关重要的角色, 开发高通量的PPI …
生物学过程, 在细胞的基本生命过程中扮演了至关重要的角色, 开发高通量的PPI …