Calcium-and voltage-gated BK channels in vascular smooth muscle

AM Dopico, AN Bukiya, JH Jaggar - Pflügers Archiv-European Journal of …, 2018 - Springer
Ion channels in vascular smooth muscle regulate myogenic tone and vessel contractility. In
particular, activation of calcium-and voltage-gated potassium channels of large conductance …

The blood–brain barrier and the neurovascular unit in subarachnoid hemorrhage: molecular events and potential treatments

P Solár, A Zamani, K Lakatosová, M Joukal - Fluids and Barriers of the …, 2022 - Springer
The response of the blood–brain barrier (BBB) following a stroke, including subarachnoid
hemorrhage (SAH), has been studied extensively. The main components of this reaction are …

Nitric oxide, endothelium‐derived hyperpolarizing factor, and smooth muscle‐dependent mechanisms contribute to magnesium‐dependent vascular relaxation in …

O Kudryavtseva, KS Lyngsø, BL Jensen… - Acta …, 2024 - Wiley Online Library
Abstract Aim Magnesium (Mg2+) is a vasorelaxant. The underlying physiological
mechanisms driving this vasorelaxation remain unclear. Studies were designed to test the …

Activation of endothelial large conductance potassium channels protects against TNF-α-induced inflammation

T Zyrianova, K Zou, B Lopez, A Liao, C Gu… - International journal of …, 2023 - mdpi.com
Elevated TNF-α levels in serum and broncho-alveolar lavage fluid of acute lung injury
patients correlate with mortality rates. We hypothesized that pharmacological plasma …

VEGFR2 in vascular smooth muscle cells mediates H2S-induced dilation of the rat cerebral basilar artery

J Chen, X Ding, W Chen, S Chen, Q Guan, J Wen… - Microvascular …, 2022 - Elsevier
Introduction The aim of present study was to study whether the vascular endothelial growth
factor receptor 2 (VEGFR 2) mediates hydrogen sulfide (H 2 S)-induced relaxation of the rat …

Magnesium sulfate suppresses L-type calcium currents on the basilar artery smooth muscle cells in rabbits

N Sharma, DH Cho, SY Kim, JP Bhattarai… - Neurological …, 2012 - Taylor & Francis
Objectives: Although magnesium is a well-known treatment for vasospasm following
subarachnoid hemorrhage, its mechanism of action for cerebral vascular relaxation is not …

[PDF][PDF] Extracellular Mg2+ level affects the major mechanism of endothelium-dependent relaxation in resistance arteries

M Constantin, DN ŞERBAN, C PRICOP… - …, 2019 - farmaciajournal.com
Mg2+ affects vascular smooth muscle contraction by direct and endothelium-dependent
pathways. The major mechanism of endothelium-dependent relaxation (EDR) in resistance …

Effects of cisplatin on potassium currents in CT26 cells

N Sharma, JP Bhattarai, SY Kim… - Journal of Cancer …, 2016 - journals.lww.com
Aims: Cisplatin, a platinum-based drug, is an important weapon against many types of
cancer. It is well-known that cisplatin induces apoptosis. Potassium channel plays very …

[PDF][PDF] 不同标签辅助的IBTX 原核表达纯化及活性鉴定

赵志文, 张峥, 刘浩文, 黄智刚, 吴颖 - 现代生物医学进展, 2014 - biomed.cnjournals.com
摘要目的: 在原核体系中建立高效表达纯化IBTX (Iberiotoxin) 的工艺, 并比较不同标签对IBTX
生物活性的影响. 方法: 利用引物搭桥的方法, 经PCR 扩增, 获得IBTX 编码基因 …

[PDF][PDF] 双源CT 三维重建前交叉韧带移植物新技术

李光政, 韩先伟, 徐虎, 王迎春, 张春礼 - 现代生物医学进展, 2014 - biomed.cnjournals.com
摘要目的: 探讨双源CT (DSCT) 三维重建前交叉韧带(anterior cruciate ligament, ACL)
重建术后移植物的技术方法. 方法: 对30 例ACL 损伤后移植重建术后患者进行DSCT 扫描 …