Pharmacokinetic and pharmacodynamic considerations for antifungal therapy optimisation in the treatment of intra-abdominal candidiasis
E Novy, C Roger, JA Roberts, MO Cotta - Critical Care, 2023 - Springer
Intra-abdominal candidiasis (IAC) is one of the most common of invasive candidiasis
observed in critically ill patients. It is associated with high mortality, with up to 50% of deaths …
observed in critically ill patients. It is associated with high mortality, with up to 50% of deaths …
Intra-abdominal infections survival guide: a position statement by the Global Alliance For Infections In Surgery
M Sartelli, P Barie, V Agnoletti, MN Al-Hasan… - World Journal of …, 2024 - Springer
Intra-abdominal infections (IAIs) are an important cause of morbidity and mortality in hospital
settings worldwide. The cornerstones of IAI management include rapid, accurate …
settings worldwide. The cornerstones of IAI management include rapid, accurate …
Population pharmacokinetic modeling and target attainment analyses of rezafungin for the treatment of candidemia and invasive candidiasis
S Roepcke, J Passarell, H Walker… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Rezafungin is a chemically and metabolically stable echinocandin with a longer half-life
than other echinocandins, allowing for a once-weekly intravenous infusion versus a daily …
than other echinocandins, allowing for a once-weekly intravenous infusion versus a daily …
Absence of clinically meaningful drug-drug interactions with rezafungin: outcome of investigations
S Flanagan, H Walker, V Ong… - Microbiology Spectrum, 2023 - Am Soc Microbiol
Rezafungin is a novel once-weekly echinocandin for intravenous injection currently in
development for the treatment of Candida infections and the prevention of Candida …
development for the treatment of Candida infections and the prevention of Candida …
[HTML][HTML] Tolerability of pulsed high-dose L-AmB as pre-emptive therapy in patients at high risk for intra-abdominal candidiasis: a phase 2 study (LAMBDA study)
M Rinaldi, M Bartoletti, C Bonazzetti, N Caroccia… - International Journal of …, 2023 - Elsevier
Background Intra-abdominal candidiasis (IAC) has a high mortality rate. However, the
correct management of a critically ill patient with suspected IAC remains unclear. The aim of …
correct management of a critically ill patient with suspected IAC remains unclear. The aim of …
Pharmacokinetics of Voriconazole in peritoneal fluid of critically Ill patients
X Lin, X Hu, Z Tang, P Guo, X Liu, T Liang… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Data on the distribution of voriconazole (VRC) in the human peritoneal cavity are sparse.
This prospective study aimed to describe the pharmacokinetics of intravenous VRC in the …
This prospective study aimed to describe the pharmacokinetics of intravenous VRC in the …
Management of intra-abdominal infections: recommendations by the Italian council for the optimization of antimicrobial use
Intra-abdominal infections (IAIs) are common surgical emergencies and are an important
cause of morbidity and mortality in hospital settings, particularly if poorly managed. The …
cause of morbidity and mortality in hospital settings, particularly if poorly managed. The …
[HTML][HTML] Human tissue distribution of caspofungin
J Marx, V Reinstadler, T Gasperetti, R Welte… - International Journal of …, 2022 - Elsevier
Tissue concentrations of caspofungin were determined in nine clinically relevant tissues
taken during routine autopsy of 20 patients who had died during caspofungin treatment or …
taken during routine autopsy of 20 patients who had died during caspofungin treatment or …
[引用][C] Target-site Pharmacokinetics and Pharmacodynamics of Echinocandins
T Gasperetti, R Bellmann