The human immune system has developed an elaborate network of cascades for dealing
with microbial intruders. Owing to its ability to rapidly recognize and eliminate …

Phagocytosis, an important mechanism of the host‐defence system and a primary function of
macrophages, is facilitated by opsonization, a process by which serum components tag …

The major emphasis of this updated version of Practice Parameters for Allergy Diagnostic
Testing is focused on how technological refinements and their validations during the past …

Atypical hemolytic uremic syndrome (aHUS) is a disease of complement dysregulation. In
approximately 50% of patients, mutations have been described in the genes encoding the …

Activation of the complement system and resulting opsonisation with C3b are key events of
the innate immune defense against infections. However, a wide variety of bacterial …

The complement system is a key part of the innate immune system, and is required for
clearance of pathogens from the bloodstream. After exposure to pathogens, the third …

The complement and coagulation systems are two related protein cascades in plasma that
serve important roles in host defense and hemostasis, respectively. Complement activation …

The evolutionary history of complement suggests that the alternative pathway arose prior to
the arrival of the classical and lectin pathways. In these pathways, target specificity is …

Background The complement system is an essential component of our innate defense and
plays a vital role in the pathogenesis of many diseases. Assessment of complement …

Complement activation on cell surfaces leads to the massive deposition of C3b, iC3b, and
C3dg, the main complement opsonins. Recognition of iC3b by complement receptor type 3 …