Overview of the most promising radionuclides for targeted alpha therapy: The “hopeful eight”
Among all existing radionuclides, only a few are of interest for therapeutic applications and
more specifically for targeted alpha therapy (TAT). From this selection, actinium-225 …
more specifically for targeted alpha therapy (TAT). From this selection, actinium-225 …
Bismuth-213 for targeted radionuclide therapy: from atom to bedside
S Ahenkorah, I Cassells, CM Deroose, T Cardinaels… - Pharmaceutics, 2021 - mdpi.com
In contrast to external high energy photon or proton therapy, targeted radionuclide therapy
(TRNT) is a systemic cancer treatment allowing targeted irradiation of a primary tumor and …
(TRNT) is a systemic cancer treatment allowing targeted irradiation of a primary tumor and …
Tailoring radiotherapies and nanotechnology for targeted treatment of solid tumors
Existing anticancer therapeutic modalities in clinical settings lack efficacy and fail to
completely cure cancers. Clearly understandable and mechanistic approaches are …
completely cure cancers. Clearly understandable and mechanistic approaches are …
Small-scale (sub-organ and cellular level) alpha-particle dosimetry methods using an iQID digital autoradiography imaging system
R Peter, BM Sandmaier, MP Dion, SHL Frost… - Scientific reports, 2022 - nature.com
Targeted radiopharmaceutical therapy with alpha-particle emitters (αRPT) is advantageous
in cancer treatment because the short range and high local energy deposition of alpha …
in cancer treatment because the short range and high local energy deposition of alpha …
A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells
X Liu, L Luan, X Liu, D Jiang, J Deng, J Xu… - Frontiers in …, 2023 - frontiersin.org
Human epithelial growth factor receptor-2 (HER2) plays an oncogenic role in numerous
tumors, including breast, gastric, and various other solid tumors. While anti-HER2 therapies …
tumors, including breast, gastric, and various other solid tumors. While anti-HER2 therapies …
Evaluation of [89Zr]Zr-DFO-2Rs15d Nanobody for Imaging of HER2-Positive Breast Cancer
M Ducharme, L Hall, W Eckenroad… - Molecular …, 2023 - ACS Publications
One of the most aggressive forms of breast cancer involves the overexpression of human
epidermal growth factor receptor 2 (HER2). HER2 is overexpressed in∼ 25% of all breast …
epidermal growth factor receptor 2 (HER2). HER2 is overexpressed in∼ 25% of all breast …
Site-specific Radiohalogenation of a HER2-targeted single-domain antibody fragment using a Novel Residualizing Prosthetic agent
Y Feng, SM Sarrett, RL Meshaw… - Journal of medicinal …, 2022 - ACS Publications
Because of their rapid tumor accumulation and normal tissue clearance, single-domain
antibody fragments (sdAbs) are an attractive vehicle for developing radiotherapeutics …
antibody fragments (sdAbs) are an attractive vehicle for developing radiotherapeutics …
[HTML][HTML] 3p-C-NETA: A versatile and effective chelator for development of Al18F-labeled and therapeutic radiopharmaceuticals
Background: Radiolabeled somatostatin analogues (eg [68 Ga] Ga-DOTATATE and [177 Lu]
Lu-DOTATATE) have been used to diagnose, monitor, and treat neuroendocrine tumour …
Lu-DOTATATE) have been used to diagnose, monitor, and treat neuroendocrine tumour …
86Y-labeled albumin-binding fibroblast activation protein inhibitor for late-time-point cancer diagnosis
J Ding, M Xu, J Chen, P Zhang, L Huo… - Molecular …, 2022 - ACS Publications
Fibroblast activation protein inhibitor (FAPI) is a novel quinoline-based radiopharmaceutical
that has theranostic potential, yet the limited tumor retention hinders late-time diagnosis and …
that has theranostic potential, yet the limited tumor retention hinders late-time diagnosis and …
Effective treatment of human breast carcinoma xenografts with single-dose 211At-labeled anti-HER2 single-domain antibody fragment
Y Feng, R Meshaw, XG Zhao, S Jannetti… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Single-domain antibody fragments (sdAbs) are attractive for targeted α-particle therapy,
particularly with 211At, because of their rapid accumulation in tumor and clearance from …
particularly with 211At, because of their rapid accumulation in tumor and clearance from …