State-of-the-art biocatalysis

JB Pyser, S Chakrabarty, EO Romero… - ACS central …, 2021 - ACS Publications
The use of enzyme-mediated reactions has transcended ancient food production to the
laboratory synthesis of complex molecules. This evolution has been accelerated by …

Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function

JD Rudolf, CY Chang, M Ma, B Shen - Natural Product Reports, 2017 - pubs.rsc.org
Covering: up to January 2017 Cytochrome P450 enzymes (P450s) are some of the most
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …

[HTML][HTML] Dirigent gene editing of gossypol enantiomers for toxicity-depleted cotton seeds

JL Lin, X Fang, JX Li, ZW Chen, WK Wu, XX Guo… - Nature Plants, 2023 - nature.com
Axial chirality of biaryls can generate varied bioactivities. Gossypol is a binaphthyl
compound made by cotton plants. Of its two axially chiral isomers,(−)-gossypol is the …

NCBI BLAST+ integrated into Galaxy

PJA Cock, JM Chilton, B Grüning, JE Johnson… - …, 2015 - academic.oup.com
Abstract Background The NCBI BLAST suite has become ubiquitous in modern molecular
biology and is used for small tasks such as checking capillary sequencing results of single …

Building bridges: Biocatalytic C–C-bond formation toward multifunctional products

NG Schmidt, E Eger, W Kroutil - ACS catalysis, 2016 - ACS Publications
Carbon–carbon bond formation is the key reaction for organic synthesis to construct the
carbon framework of organic molecules. The review gives a selection of biocatalytic C–C …

Laccase catalysis for the synthesis of bioactive compounds

T Kudanga, B Nemadziva, M Le Roes-Hill - Applied Microbiology and …, 2017 - Springer
The demand for compounds of therapeutic value is increasing mainly because of new
applications of bioactive compounds in medicine, pharmaceutical, agricultural, and food …

[HTML][HTML] Broadening the scope of biocatalytic C–C bond formation

LE Zetzsche, ARH Narayan - Nature Reviews Chemistry, 2020 - nature.com
Enzymes exercise impeccable control over chemoselectivity, site selectivity and
stereoselectivity in reactions they mediate, such that we have witnessed a surge in the …

The ocean sampling day consortium

A Kopf, M Bicak, R Kottmann, J Schnetzer, I Kostadinov… - Gigascience, 2015 - Springer
Abstract Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial
Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine …

Regio-and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis

W Hüttel, M Müller - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2005 to 2020 Phenol coupling is a key reaction in the biosynthesis of important
biopolymers such as lignin and melanin and of a plethora of biarylic secondary metabolites …

Substrate oxidation by cytochrome P450 enzymes

PR Ortiz de Montellano - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Cytochrome P450 enzymes catalyze a broad diversity of reactions, including well-
established transformations such as carbon and nitrogen hydroxylation, heteroatom …