A variety of engineered materials have gained acceptance in orthopedic practice as
substitutes for autologous bone grafts, although the regenerative efficacy of these …

Interest in strontium (Sr) has persisted over the last three decades due to its unique
mechanism of action: it simultaneously promotes osteoblast function and inhibits osteoclast …

Background Distraction osteogenesis (DO) is a functional tissue engineering approach that
applies gradual mechanical traction on the bone tissues after osteotomy to stimulate bone …

The ability to direct cell behavior has been central to the success of numerous therapeutics
to regenerate tissue or facilitate device integration. Biomaterial scientists are challenged to …

MicroRNAs (miRNAs) are a family of small, single-stranded, and non-protein coding RNAs
about 19 to 22 nucleotides in length, that have been reported to have important roles in the …

In dentistry, problems of craniofacial, osteochondral, periodontal tissue, nerve, pulp or
endodontics injuries, and osteoarthritis need regenerative therapy. The use of stem cells in …

Annual bone grafting surgeries due to bone fractures, resections of affected bones, skeletal
anomalies, osteoporosis, etc. exceed two million worldwide. In this regard, the creation of …

Although bone possesses a remarkable capacity for self-remodeling and self-healing of
small defects, the continuously increasing growth of bone diseases in the elderly population …

Distraction osteogenesis (DO) is a mechanobiological process of regenerating bone tissue
by tension stress. DO is used clinically to lengthen bones or to treat critical size bone …

Bones are constantly exposed to mechanical forces from both muscles and Earth's gravity to
maintain bone homeostasis by stimulating bone formation. Mechanotransduction transforms …