The ability to generate germ cells from pluripotent stem cells (PSCs) is valuable for human
regenerative medicine and animal breeding. Germ cell-like cells (GCLCs) have been …

It has been reported that suboptimal in vitro culture (IVC) of mouse embryos can affect the
postnatal expression of epigenetically sensitive alleles, resulting in altered postnatal growth …

DNA methylation is a chemical modification of DNA involved in the regulation of gene
expression by controlling the access to the DNA sequence. It is the most stable epigenetic …

The recent successful establishment of mouse parthenogenetic haploid embryonic stem
cells (phESCs) and androgenetic haploid ESCs (ahESCs) has stimulated genetic research …

An oocyte can activate its developmental process without the intervention of the male
counterpart. This form of reproduction, known as parthenogenesis, occurs spontaneously in …

It remains controversial whether the abnormal epigenetic modifications accumulated in the
induced pluripotent stem cells (iPSCs) can ultimately affect iPSC pluripotency. To probe this …

Mammalian parthenogenetic embryos are not viable and die because of defects in placental
development and genomic imprinting. Parthenogenetic ESCs (pESCs) derived from …

OBJECTIVE: To suggest an alternative strategy for deriving histocompatible stems cells
without undertaking genetic manipulation. DESIGN: Prospective approach using an animal …

Parthenogenetic embryos, created by activation and diploidization of oocytes, arrest at mid-
gestation for defective paternal imprints, which impair placental development. Also, viable …

Mouse embryonic stem (ES) cell cultures exhibit heterogeneity and recently are discovered
to sporadically enter the 2-cell (2C)-embryo state, critical for ES potency. Zscan4 could mark …