Objective: To provide updated evidence-based recommendations for the preventive
treatment of migraine headache. The clinical question addressed was: What pharmacologic …

Objective While there are several trials that support the efficacy of various drugs for migraine
prophylaxis against placebo, there is limited evidence addressing the comparative safety …

Background Several drugs are available for the preventive treatment of both episodic and
chronic migraine. The choice of which therapy to initiate first, second, or third is not …

Objective To compare the effectiveness and side effects of migraine prophylactic
medications. Design We performed a network meta-analysis. Data were extracted …

Importance When analyzing results of randomized clinical trials, the treatment with the
greatest specific effect compared with its placebo control is considered to be the most …

Objective: To provide updated evidence-based recommendations for the preventive
treatment of migraine headache. The clinical question addressed was: Are nonsteroidal anti …

Introduction and objective Monoclonal antibodies targeting the calcitonin gene-related
peptide pathway (anti-CGRP mAbs) have shown promising efficacy in randomised clinical …

In analgesic clinical trials, adverse events are reported for the painkiller under evaluation
and compared with adverse events in the placebo group. Interestingly, patients who receive …

Background The approval of monoclonal antibodies for prevention of migraine has
revolutionized treatment for patients. Oral preventatives are still considered first line …

Background Head-to-head comparator trials between first-line oral migraine preventatives
and the new monoclonal antibodies (mAbs) blocking the calcitonin gene-related peptide …