Highlights•Drug resistance of cancer cells, which results in treatment failure, is a major
concern in medical oncology.•Ca 2+ plays an important role in acquired drug resistance by …

Innate and acquired resistances to therapeutic agents are responsible for the failure of
cancer treatments. Due to the multifactorial nature of resistance, the identification of new …

Colorectal carcinoma (CRC) represents the fourth most common cancer worldwide and is
the third most common cause of malignancy-associated mortality. Distant metastases to the …

Cancer cells must survive aberrant fluid shear stress (FSS) in the circulation to metastasize.
Herein, we investigate the role that FSS has on colorectal cancer cell apoptosis …

The purine nucleotide adenosine triphosphate (ATP) is known for its fundamental role in
cellular bioenergetics. However, in the last decades, different works have described …

Moderate levels of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), fuel
tumor metastasis and invasion in a variety of cancer types. Conversely, excessive ROS …

Colorectal cancer (CRC) is an abnormal proliferation of cells within the colon and rectum,
leading to the formation of polyps and disruption of mucosal functions. The disease …

ABSTRACT Introduction The Ca2+ signaling toolkit is currently under investigation as a
potential target for addressing the threat of cancer. A growing body of evidence suggests …

Breast cancer (BC) is the second most common cancer and cause of death in women. The
aggressive subtypes including triple negative types (TNBCs) show a resistance to …

Intracellular calcium signaling regulates diverse physiological and pathological processes.
In solid tumors, changes to calcium channels and effectors via mutations or changes in …