Use of mass spectrometry for imaging metabolites in plants

YJ Lee, DC Perdian, Z Song, ES Yeung… - The Plant …, 2012 - Wiley Online Library
We discuss and illustrate recent advances that have been made to image the distribution of
metabolites among cells and tissues of plants using different mass spectrometry …

MALDI-TOF mass spectrometry: a versatile tool for high-performance DNA analysis

C Jurinke, P Oeth, D van den Boom - Molecular biotechnology, 2004 - Springer
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry
(MS) has developed during the past decade into a versatile tool for biopolymer analysis. The …

Origin of life: protoribosome forms peptide bonds and links RNA and protein dominated worlds

T Bose, G Fridkin, C Davidovich, M Krupkin… - Nucleic acids …, 2022 - academic.oup.com
Although the mode of action of the ribosomes, the multi-component universal effective
protein-synthesis organelles, has been thoroughly explored, their mere appearance …

Quantification of proteins and metabolites by mass spectrometry without isotopic labeling or spiked standards

W Wang, H Zhou, H Lin, S Roy, TA Shaler… - Analytical …, 2003 - ACS Publications
A new method is presented for quantifying proteomic and metabolomic profile data by liquid
chromatography− mass spectrometry (LC− MS) with electrospray ionization. This …

Identification of 491 proteins in the tear fluid proteome reveals a large number of proteases and protease inhibitors

GA de Souza, LMF de Godoy, M Mann - Genome biology, 2006 - Springer
Background The tear film is a thin layer of fluid that covers the ocular surface and is involved
in lubrication and protection of the eye. Little is known about the protein composition of tear …

Considerations for MALDI-based quantitative mass spectrometry imaging studies

F Tobias, AB Hummon - Journal of proteome research, 2020 - ACS Publications
Significant advances in mass spectrometry imaging (MSI) have pushed the boundaries in
obtaining spatial information and quantification in biological samples. Quantitative MSI …

Quantitative matrix-assisted laser desorption/ionization mass spectrometry

MW Duncan, H Roder… - Briefings in functional …, 2008 - academic.oup.com
This review summarizes the essential characteristics of matrix-assisted laser
desorption/ionization (MALDI) time-of-flight mass spectrometry (TOF MS), especially as they …

Quantitative MALDI tandem mass spectrometric imaging of cocaine from brain tissue with a deuterated internal standard

DA Pirman, RF Reich, A Kiss, RMA Heeren… - Analytical …, 2013 - ACS Publications
Mass spectrometric imaging (MSI) is an analytical technique used to determine the
distribution of individual analytes within a given sample. A wide array of analytes and …

A Caffeic Acid Matrix Improves In Situ Detection and Imaging of Proteins with High Molecular Weight Close to 200,000 Da in Tissues by Matrix-Assisted Laser …

H Liu, M Han, J Li, L Qin, L Chen, Q Hao… - Analytical …, 2021 - ACS Publications
To our knowledge, this was the first study in which caffeic acid (CA) was successfully
evaluated as a matrix to enhance the in situ detection and imaging of endogenous proteins …

Applications of MALDI-TOF mass spectrometry in clinical proteomics

V Greco, C Piras, L Pieroni, M Ronci… - Expert review of …, 2018 - Taylor & Francis
Introduction: The development of precision medicine requires advanced technologies to
address the multifactorial disease stratification and to support personalized treatments …