The origin of pattern and polarity in the Drosophila embryo

D St Johnston, C Nüsslein-Volhard - cell, 1992 - Elsevier
'The development of a multicellular organism from a single egg cell requires both the
determination of many cell types and the organization of these cells into an elaborate pattern …

The gap gene network

J Jaeger - Cellular and Molecular Life Sciences, 2011 - Springer
Gap genes are involved in segment determination during the early development of the fruit
fly Drosophila melanogaster as well as in other insects. This review attempts to synthesize …

The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo

D Weigel, G Jürgens, F Küttner, E Seifert, H Jäckle - Cell, 1989 - cell.com
The region-specific homeotic gene fork head (fkh) promotes terminal as opposed to
segmental development in the Drosophila embryo. We have cloned the f&h region by …

The spatiotemporal limits of developmental Erk signaling

HE Johnson, Y Goyal, NL Pannucci, T Schüpbach… - Developmental cell, 2017 - cell.com
Animal development is characterized by signaling events that occur at precise locations and
times within the embryo, but determining when and where such precision is needed for …

Cell shape changes during gastrulation in Drosophila

M Leptin, B Grunewald - Development, 1990 - journals.biologists.com
The first morphogenetic movement during Drosophila development is the invagination of the
mesoderm, an event that folds a one-layered epithelium into a multilayered structure. In this …

Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology.

T Schüpbach, E Wieschaus - Genetics, 1991 - academic.oup.com
In mutagenesis screens for recessive female sterile mutations on the second chromosome of
Drosophila melanogaster 528 lines were isolated which allow the homozygous females to …

Embryonic origin of hemocytes and their relationship to cell death in Drosophila

U Tepass, LI Fessler, A Aziz, V Hartenstein - Development, 1994 - journals.biologists.com
We have studied the embryonic development of Drosophila hemocytes and their conversion
into macrophages. Hemocytes derive exclusively from the mesoderm of the head and …

A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo

S Roth, D Stein, C Nüsslein-Volhard - Cell, 1989 - cell.com
The dorsoventral axis of the Drosophila embryo is determined by a morphogen gradient
established by the action of 12 maternal-effect genes: the dorsal group genes and cactus …

oskar mRNA is localized to the posterior pole of the Drosophila oocyte

J Kim-Ha, JL Smith, PM Macdonald - Cell, 1991 - cell.com
Mutants of the maternal posterior-group genes of Drosophila lack posterior body pattern
elements and germ cells, both of which form through the action of determinants localized to …

Nanos is the localized posterior determinant in Drosophila

C Wang, R Lehmann - Cell, 1991 - cell.com
Segmental pattern in the Drosophila embryo is established by two maternal factors localized
to the anterior and posterior poles of the egg cell. Here we provide molecular evidence that …