Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

Since the discovery of the DNA double helix, there has been a fascination in understanding
the molecular mechanisms and cellular processes that account for:(i) the transmission of …

Despite being the first homolog of the bacterial RecQ helicase to be identified in humans,
the function of RECQL1 remains poorly characterized. Furthermore, unlike other members of …

The gene encoding DNA polymerase θ (Polθ) was discovered over ten years ago as having
a role in suppressing genome instability in mammalian cells. Studies have now clearly …

DNA polymerase theta (Polθ) has been identified as a crucial alternative non-homologous
end-joining factor in mammalian cells. Polθ is upregulated in a range of cancer cell types …

Small molecules that deter the functions of DNA damage response machinery are
postulated to be useful for enhancing the DNA damaging effects of chemotherapy or ionizing …

RAD51 recombinase plays a central role in homologous recombination (HR) by forming a
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …

Friedreich's ataxia (FRDA) is caused by expansions of GAA• TTC repeats in the first intron of
the human FXN gene that occur during both intergenerational transmissions and in somatic …

Bloom's syndrome helicase (BLM) is a member of the RecQ family of DNA helicases, which
play key roles in the maintenance of genome integrity in all organism groups. We describe …

The RecQ-like helicase BLM cooperates with topoisomerase IIIα, RMI1, and RMI2 in a
heterotetrameric complex (the “Bloom syndrome complex”) for dissolution of double Holliday …