The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities

Z Huang, AH Rose, PR Hoffmann - Antioxidants & redox signaling, 2012 - liebertpub.com
Abstract Dietary selenium (] Se), mainly through its incorporation into selenoproteins, plays
an important role in inflammation and immunity. Adequate levels of Se are important for …

Selenoproteins: Antioxidant selenoenzymes and beyond

H Steinbrenner, B Speckmann, LO Klotz - Archives of Biochemistry and …, 2016 - Elsevier
Adequate intake of the essential trace element and micronutrient selenium is thought to be
beneficial for maintaining human health. Selenium may modulate a broad spectrum of key …

Selenoprotein P–Selenium transport protein, enzyme and biomarker of selenium status

L Schomburg - Free Radical Biology and Medicine, 2022 - Elsevier
The habitual intake of selenium (Se) varies strongly around the world, and many people are
at risk of inadequate supply and health risks from Se deficiency. Within the human organism …

[HTML][HTML] Selenoprotein K protects skeletal muscle from damage and is required for satellite cells-mediated myogenic differentiation

S Wang, X Zhao, Q Liu, Y Wang, S Li, S Xu - Redox biology, 2022 - Elsevier
The regeneration of adult skeletal muscle after injury is primarily initiated by satellite cells
(SCs), but the regulatory mechanisms of cells committed to myogenic differentiation remain …

Oxidative stress and metabolic pathologies: from an adipocentric point of view

S Le Lay, G Simard, MC Martinez… - Oxidative medicine …, 2014 - Wiley Online Library
Oxidative stress plays a pathological role in the development of various diseases including
diabetes, atherosclerosis, or cancer. Systemic oxidative stress results from an imbalance …

Nutritional status of selenium in overweight and obesity: A systematic review and meta-analysis

LC Fontenelle, DSC de Araújo, T da Cunha Soares… - Clinical Nutrition, 2022 - Elsevier
Background & aims Selenium is an antioxidant and anti-inflammatory nutrient and regulates
important physiological processes, such as carbohydrate and lipid metabolism, immune …

[HTML][HTML] Dietary selenium alleviated mouse liver oxidative stress and NAFLD induced by obesity by regulating the KEAP1/NRF2 pathway

Y Wang, B Liu, P Wu, Y Chu, S Gui, Y Zheng, X Chen - Antioxidants, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) occurs when excess fat is stored in the liver and it
is strongly linked with metabolic syndrome and oxidative stress. Selenium (Se) is an …

[HTML][HTML] Selenium and selenoproteins in adipose tissue physiology and obesity

AA Tinkov, OP Ajsuvakova, T Filippini, JC Zhou, XG Lei… - Biomolecules, 2020 - mdpi.com
Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its
possible roles in obesity development and in adipocyte metabolism are unclear. The …

Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis

SJ Yang, SY Hwang, HY Choi, HJ Yoo… - The Journal of …, 2011 - academic.oup.com
Abstract Context and Objective: The dysregulation of hepatokines may be associated with
the pathogenesis of insulin resistance and type 2 diabetes. A recent study has suggested …

[HTML][HTML] The two faces of reactive oxygen species (ROS) in adipocyte function and dysfunction

JP Castro, T Grune, B Speckmann - Biological chemistry, 2016 - degruyter.com
White adipose tissue (WAT) is actively involved in the regulation of whole-body energy
homeostasis via storage/release of lipids and adipokine secretion. Current research links …