Smart nanomaterials as the foundation of a combination approach for efficient cancer theranostics

S Panda, S Hajra, A Kaushik, HG Rubahn… - Materials Today …, 2022 - Elsevier
Despite numerous FDA-approved treatment and diagnostic approaches, cancer is one of the
leading causes of death worldwide due to delayed diagnostics and the limited efficacy of …

Development of Thiol-Maleimide hydrogels incorporating graphene-based nanomaterials for cancer chemo-photothermal therapy

FJP Costa, M Nave, R Lima-Sousa, CG Alves… - International Journal of …, 2023 - Elsevier
Nano-sized materials have been widely explored in the biomedicine field, especially due to
their ability to encapsulate drugs intended to be delivered to cancer cells. However …

Chitosan-based injectable in situ forming hydrogels containing dopamine-reduced graphene oxide and resveratrol for breast cancer chemo-photothermal therapy

BL Melo, R Lima-Sousa, CG Alves, AF Moreira… - Biochemical …, 2022 - Elsevier
Strategies combining nanomaterials' chemotherapy and photothermal therapy hold an
enormous potential for improving cancer treatment. Still, the translation of this modality has …

Mitoxantrone-loaded lipid nanoparticles for breast cancer therapy–Quality-by-design approach and efficacy assessment in 2D and 3D in vitro cancer models

A Granja, R Lima-Sousa, CG Alves… - International journal of …, 2021 - Elsevier
Breast cancer is the leading cause of cancer-related deaths among women worldwide. The
conventional chemotherapeutic regimens used in the treatment of this disease often lead to …

Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT

M Nave, FJP Costa, CG Alves, R Lima-Sousa… - European Journal of …, 2023 - Elsevier
Near infrared (NIR) light-responsive nanomaterials hold potential to mediate combinatorial
therapies targeting several cancer hallmarks. When irradiated, these nanomaterials produce …

Injectable in situ forming hydrogels incorporating dual-nanoparticles for chemo-photothermal therapy of breast cancer cells

IJ Sabino, R Lima-Sousa, CG Alves, BL Melo… - International Journal of …, 2021 - Elsevier
Chemo-photothermal therapy (chemo-PTT) mediated by nanomaterials holds a great
potential for cancer treatment. However, the tumor uptake of the systemically administered …

Poly (2-ethyl-2-oxazoline) functionalized reduced graphene oxide: Optimization of the reduction process using dopamine and application in cancer photothermal …

R Lima-Sousa, CG Alves, BL Melo, AF Moreira… - Materials Science and …, 2021 - Elsevier
The high near infrared (NIR) absorption displayed by reduced graphene oxide (rGO)
nanostructures renders them a great potential for application in cancer photothermal …

3D imaging and quantification of PLL coated fluorescent ZnO NP distribution and ROS accumulation using laser scanning confocal microscopy

A Dey, S Gare, S Swain, P Bhattacharya… - AIChE …, 2022 - Wiley Online Library
Investigations on nanomedicine involve conventional two dimensional (2D) imaging
techniques for observing the nanoparticle internalization at a single time point where various …

Poly (2-ethyl-2-oxazoline)–IR780 conjugate nanoparticles for breast cancer phototherapy

CG Alves, R Lima-Sousa, BL Melo, P Ferreira… - …, 2022 - Taylor & Francis
Aims: To address the limitations of IR780 by preparing hydrophilic polymer–IR780
conjugates and to employ these conjugates in the assembly of nanoparticles (NPs) intended …

Colorectal cancer and immunity: from the wet lab to individuals

E Pramil, C Dillard, AE Escargueil - Cancers, 2021 - mdpi.com
Simple Summary Tackling the current dilemma of colorectal cancer resistance to
immunotherapy is puzzling and requires novel therapeutic strategies to emerge. However …