Integrins are the principal cell adhesion receptors that mediate leukocyte migration and
activation in the immune system. These receptors signal bidirectionally through the plasma …

Chemotaxis, or directed migration of cells along a chemical gradient, is a highly coordinated
process that involves gradient sensing, motility, and polarity. Most of our understanding of …

Bloodstream infection is a hallmark of sepsis, a medically emergent condition requiring rapid
treatment. However, up-regulation of host defense proteins through Toll-like receptors …

Molecular danger signals attract neutrophilic granulocytes (polymorphonuclear leukocytes
(PMNs)) to sites of infection. The G protein-coupled receptor (GPR) 43 recognizes …

β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …

Malformed α-Synuclein (α-syn) aggregates in neurons are released into the extracellular
space, activating microglia to induce chronic neuroinflammation that further enhances …

L-selectin is a type I transmembrane cell adhesion molecule expressed on most circulating
leukocytes, including neutrophils. Engagement of L-selectin with endothelial-derived ligands …

Hepatic ischemia and reperfusion elicits an immune response that lacks a microbial
constituent yet poses a potentially lethal threat to the host. In this sterile setting, the immune …

Interactions among leukocytes and leukocytes with immune-associated auxiliary cells
represent an essential feature of the immune response that requires the involvement of cell …

Macrophage migration inhibitory factor (MIF) was originally identified for its ability to inhibit
the random migration of macrophages in vitro. MIF is now recognized as an important …