Pathogenesis of allergic diseases and implications for therapeutic interventions
J Wang, Y Zhou, H Zhang, L Hu, J Liu, L Wang… - Signal transduction and …, 2023 - nature.com
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …
The impact of perinatal immune development on mucosal homeostasis and chronic inflammation
H Renz, P Brandtzaeg, M Hornef - Nature Reviews Immunology, 2012 - nature.com
The mucosal surfaces of the gut and airways have important barrier functions and regulate
the induction of immunological tolerance. The rapidly increasing incidence of chronic …
the induction of immunological tolerance. The rapidly increasing incidence of chronic …
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation
M Kurowska-Stolarska, B Stolarski, P Kewin… - The Journal of …, 2009 - journals.aai.org
Alternatively activated macrophages (AAM) play a crucial role in type 2 immunity. Mice
deficient in ST2, a receptor for the latest member of the IL-1 family, IL-33, have impaired type …
deficient in ST2, a receptor for the latest member of the IL-1 family, IL-33, have impaired type …
An exposome perspective: Early-life events and immune development in a changing world
Advances in metagenomics, proteomics, metabolomics, and systems biology are providing a
new emphasis in research; interdisciplinary work suggests that personalized medicine is on …
new emphasis in research; interdisciplinary work suggests that personalized medicine is on …
[HTML][HTML] Chronic inflammation and asthma
JR Murdoch, CM Lloyd - Mutation Research/Fundamental and Molecular …, 2010 - Elsevier
Allergic asthma is a complex and chronic inflammatory disorder which is associated with
airway hyper-responsiveness and tissue remodelling of the airway structure. Although …
airway hyper-responsiveness and tissue remodelling of the airway structure. Although …
Toll-like receptor agonists as adjuvants for allergen immunotherapy
ME Kirtland, DC Tsitoura, SR Durham… - Frontiers in …, 2020 - frontiersin.org
Toll-like receptors (TLRs) are essential components of innate immunity and provide
defensive inflammatory responses to invading pathogens. Located within the plasma …
defensive inflammatory responses to invading pathogens. Located within the plasma …
Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
E Cario, G Gerken, DK Podolsky - Gastroenterology, 2007 - Elsevier
Background & Aims: Toll-like receptors (TLRs) represent a class of transmembrane pattern
recognition receptors essential for microbial recognition and control of innate immune …
recognition receptors essential for microbial recognition and control of innate immune …
IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4
M Kurowska-Stolarska, P Kewin, G Murphy… - The Journal of …, 2008 - journals.aai.org
Abstract Type 2 cytokines (IL-4, IL-5, and IL-13) play a pivotal role in helminthic infection and
allergic disorders. CD4+ T cells which produce type 2 cytokines can be generated via IL-4 …
allergic disorders. CD4+ T cells which produce type 2 cytokines can be generated via IL-4 …
The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia
CA Cowardin, EL Buonomo, MM Saleh… - Nature …, 2016 - nature.com
Clostridium difficile is the most common hospital acquired pathogen in the USA, and
infection is, in many cases, fatal. Toxins A and B are its major virulence factors, but …
infection is, in many cases, fatal. Toxins A and B are its major virulence factors, but …
IL-33 exacerbates eosinophil-mediated airway inflammation
B Stolarski, M Kurowska-Stolarska, P Kewin… - The Journal of …, 2010 - journals.aai.org
IL-33 has emerged as an important mediator in the immunopathogenesis of allergy and
asthma. However, the role of IL-33 in eosinophil-mediated inflammation has not been fully …
asthma. However, the role of IL-33 in eosinophil-mediated inflammation has not been fully …