Importance Clinicians, patients, and policy makers rely on published results from clinical
trials to help make evidence-informed decisions. To critically evaluate and use trial results …

Deep learning (DL) has the potential to transform medical diagnostics. However, the
diagnostic accuracy of DL is uncertain. Our aim was to evaluate the diagnostic accuracy of …

Background High rates of overdiagnosis are a critical barrier to organized prostate cancer
screening. Magnetic resonance imaging (MRI) with targeted biopsy has shown the potential …

Objectives To describe the processes used to update the PRISMA 2009 statement for
reporting systematic reviews, present results of a survey conducted to inform the update …

Background The efficacy of ivermectin in preventing hospitalization or extended observation
in an emergency setting among outpatients with acutely symptomatic coronavirus disease …

Importance Extenuating circumstances can trigger unplanned changes to randomized trials
and introduce methodological, ethical, feasibility, and analytical challenges that can …

Objective The vitamin D endocrine system may have a variety of actions on cells and tissues
involved in COVID-19 progression especially by decreasing the Acute Respiratory Distress …

Importance The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of
people worldwide. Tocilizumab has shown promising results in retrospective studies in …

Background Ivermectin, an antiparasitic agent used to treat parasitic infestations, inhibits the
replication of viruses in vitro. The molecular hypothesis of ivermectin's antiviral mode of …

Study Design Item 5. Indicate if the study is retrospective or prospective. Evaluate predictive
models in a prospective setting, if possible. Item 6. Define the study's goal, such as model …