Optogenetics is widely used to interrogate the neural circuits underlying disease and has
most recently been harnessed for therapeutic applications. The optogenetic toolkit consists …

Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the
cellular and molecular pathophysiological processes in stroke have been a top priority. Long …

Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …

Near-infrared (NIR) optogenetic systems for transcription regulation are in high demand
because NIR light exhibits low phototoxicity, low scattering, and allows combining with …

Genetically encoded tools for the regulation of endogenous molecules (RNA, DNA elements
and protein) are needed to study and control biological processes with minimal interference …

During animal development, the spatiotemporal properties of molecular events largely
determine the biological outcomes. Conventional gene analysis methods lack the …

Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery
after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs …

Background The relationship between monogenic and polygenic forms of epilepsy is poorly
understood and the extent to which the genetic and acquired epilepsies share common …

Highlights•Optogenetics uses light to control genetically encoded cell components.•It is a
precise tool for systematically addressing complex biological questions.•It has a potential for …

Chromatin modifications play a crucial role in the regulation of gene expression. The
repressor element-1 (RE1) silencing transcription factor (REST), also known as neuron …