An integrated, structure-and energy-based view of the genetic code
H Grosjean, E Westhof - Nucleic acids research, 2016 - academic.oup.com
The principles of mRNA decoding are conserved among all extant life forms. We present an
integrative view of all the interaction networks between mRNA, tRNA and rRNA: the intrinsic …
integrative view of all the interaction networks between mRNA, tRNA and rRNA: the intrinsic …
How do cells cope with RNA damage and its consequences?
Similar to many other biological molecules, RNA is vulnerable to chemical insults from
endogenous and exogenous sources. Noxious agents such as reactive oxygen species or …
endogenous and exogenous sources. Noxious agents such as reactive oxygen species or …
Transcriptome-wide mapping of internal N7-methylguanosine methylome in mammalian mRNA
Summary N 7-methylguanosine (m 7 G) is a positively charged, essential modification at the
5′ cap of eukaryotic mRNA, regulating mRNA export, translation, and splicing. m 7 G also …
5′ cap of eukaryotic mRNA, regulating mRNA export, translation, and splicing. m 7 G also …
Visualization of chemical modifications in the human 80S ribosome structure
SK Natchiar, AG Myasnikov, H Kratzat, I Hazemann… - Nature, 2017 - nature.com
Chemical modifications of human ribosomal RNA (rRNA) are introduced during biogenesis
and have been implicated in the dysregulation of protein synthesis, as is found in cancer …
and have been implicated in the dysregulation of protein synthesis, as is found in cancer …
Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress
M Stoneley, RF Harvey, TE Mulroney, R Mordue… - Molecular cell, 2022 - cell.com
During the translation surveillance mechanism known as ribosome-associated quality
control, the ASC-1 complex (ASCC) disassembles ribosomes stalled on the mRNA. Here …
control, the ASC-1 complex (ASCC) disassembles ribosomes stalled on the mRNA. Here …
Nucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the genetic code
TP Hoernes, N Clementi, K Faserl… - Nucleic Acids …, 2016 - academic.oup.com
Nucleotide modifications within RNA transcripts are found in every organism in all three
domains of life. 6-methyladeonsine (m6A), 5-methylcytosine (m5C) and pseudouridine (Ψ) …
domains of life. 6-methyladeonsine (m6A), 5-methylcytosine (m5C) and pseudouridine (Ψ) …
Oxidation and alkylation stresses activate ribosome-quality control
Oxidation and alkylation of nucleobases are known to disrupt their base-pairing properties
within RNA. It is, however, unclear whether organisms have evolved general mechanism (s) …
within RNA. It is, however, unclear whether organisms have evolved general mechanism (s) …
Nucleoside modifications in the regulation of gene expression: focus on tRNA
M Duechler, G Leszczyńska, E Sochacka… - Cellular and Molecular …, 2016 - Springer
Both, DNA and RNA nucleoside modifications contribute to the complex multi-level
regulation of gene expression. Modified bases in tRNAs modulate protein translation rates in …
regulation of gene expression. Modified bases in tRNAs modulate protein translation rates in …
Quality control of chemically damaged RNA
CL Simms, HS Zaher - Cellular and Molecular Life Sciences, 2016 - Springer
The “central dogma” of molecular biology describes how information contained in DNA is
transformed into RNA and finally into proteins. In order for proteins to maintain their …
transformed into RNA and finally into proteins. In order for proteins to maintain their …
Regulation of DNA alkylation damage repair: lessons and therapeutic opportunities
JM Soll, RW Sobol, N Mosammaparast - Trends in biochemical sciences, 2017 - cell.com
Alkylation chemotherapy is one of the most widely used systemic therapies for cancer. While
somewhat effective, clinical responses and toxicities of these agents are highly variable. A …
somewhat effective, clinical responses and toxicities of these agents are highly variable. A …