Cancer stem cells (CSCs), the subpopulation of cancer cells, have the capability of
proliferation, self-renewal, and differentiation. The presence of CSCs is a key factor leading …

Stem cells are proposed to continuously secrete trophic factors that potentially serve as
mediators of autocrine and paracrine activities, associated with reprogramming of the tumor …

Glioblastoma is the most common and most aggressive primary brain malignancy. The
current initial standard of care consists of maximal safe surgical resection followed by radical …

A major contributing factor to glioma development and progression is its ability to evade the
immune system. Nano-meter sized vesicles, exosomes, secreted by glioma-stem cells …

Extracellular vesicles (EVs) are small vesicles ensuring transport of molecules between cells
and throughout the body. EVs contain cell type-specific signatures and have been proposed …

The invasion properties of glioblastoma hamper a radical surgery and are responsible for its
recurrence. Understanding the invasion mechanisms is thus critical to devise new …

The ability of exosomes to elicit specific cellular responses suggests that they may be
increasingly used as therapeutics. Their vesicular nature makes them suitable as potential …

Cadherins are calcium-binding proteins with a pivotal role in cell adhesion and tissue
homeostasis. The cadherin-dependent mechanisms of cell adhesion and migration are …

Introduction Autologous fat grafting is commonly used to correct soft-tissue contour
deformities. However, results are impaired by a variable and unpredictable resorption rate …

Glioblastoma (GBM), the most aggressive and lethal brain cancer, is detected only in the
advanced stage, resulting in a median survival rate of 15 months. Therefore, there is an …