Liver fibrosis is the most important predictor of mortality in nonalcoholic fatty liver disease
(NAFLD). Quantitative risk of mortality by fibrosis stage has not been systematically …

Unlike organ transplants where an immunosuppressive environment is required, a
successful pregnancy involves an extremely robust, dynamic, and responsive maternal …

Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic
Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ …

ZBP1 is an interferon‐induced cytosolic nucleic acid sensor that facilitates antiviral
responses via RIPK3. Although ZBP1‐mediated programmed cell death is widely described …

Transforming growth factor-β (TGF-β) signaling is a critical regulator for articular cartilage
tissue maintenance and chondrocyte homeostasis. Nonetheless, the regulatory networks …

Tumor necrosis factor alpha (TNF-α) has both positive and negative roles in human disease.
In certain cancers, TNF-α is infused locally to promote tumor regression, but dose-limiting …

Inflammasomes are high molecular weight complexes that sense and react to injury and
infection. Their activation induces caspase-1 activation and release of interleukin-1β, a pro …

Abstract Backgound Ginsenoside Rb1, the main active constituent of Panax ginseng,
displays significant anti-inflammatory activity, although the mechanism has not been clearly …

Despite recent developments in diagnosis and treatment options, cancer remains one of the
most critical threats to health. Several anti-cancer therapies have been identified, but further …

The highly diverse Numb-associated kinase (NAK) family has been linked to broad cellular
functions including receptor-mediated endocytosis, Notch pathway modulation, osteoblast …