Since the breakthrough discovery of catalytic RNAs (ribozymes) in the early 1980s, valuable
ribozyme‐based gene therapies have been developed for incurable diseases ranging from …

A trans-splicing ribozyme that can specifically reprogram human telomerase reverse
transcriptase (hTERT) RNA was previously suggested as a useful tool for tumor-targeted …

AIMP2/p38 is a scaffolding protein critical for the assembly of the macromolecular tRNA
synthetase complex. Moreover, AIMP2 harbors anti-proliferative activity and promotes cell …

Group I introns have been engineered into trans-splicing ribozymes capable of replacing the
3′-terminal portion of an external mRNA with their own 3′-exon. Although this design …

Human cytoskeleton‐associated protein 2 (hCKAP2) is upregulated and highly expressed in
various human malignances. hCKAP2 has microtubule‐stabilizing characteristics and …

We previously showed that a trans-splicing ribozyme reprograms tumor-related genes at the
mRNA level, resulting in the expression of therapeutic genes and that this approach can be …

In 1982, the Cech group discovered that an intron structure in an rRNA precursor of
Tetrahymena thermophila is sufficient to complete splicing without assistance from proteins …

Background Group I intron‐based trans‐splicing ribozyme, which can specifically reprogram
human telomerase reverse transcriptase (hTERT) RNA, could be a useful tool for tumor …

Telomerase reverse transcriptase (TERT), which prolongs the replicative life span of cells, is
highly upregulated in 85-90% of human cancers, whereas most normal somatic tissues in …

Described is a unique class of antiviral molecule that can be applied to control and eliminate
HIV infection in patients using myeloablation therapies and replenishment with trans formed …