Recent developments in synthetic α-glucosidase inhibitors: A comprehensive review with structural and molecular insight
Diabetes mellitus is the prominent metabolic disorder affecting 422 million people around
the globe and cause severe associated problems like kidney disorders, heart and nervous …
the globe and cause severe associated problems like kidney disorders, heart and nervous …
Recent advances of α-glucosidase inhibitors: A comprehensive review
Background: Diabetes mellitus (DM) is a critical health issue prevailing in nearly half a
billion people worldwide. It is one of the most threatening metabolic diseases. Type 2 DM is …
billion people worldwide. It is one of the most threatening metabolic diseases. Type 2 DM is …
Synthesis and biological evaluation of indole derivatives containing thiazolidine-2, 4-dione as α-glucosidase inhibitors with antidiabetic activity
C Hu, B Liang, J Sun, J Li, Z Xiong, SH Wang… - European Journal of …, 2024 - Elsevier
In order to develop potential α-glucosidase inhibitors with antidiabetic activity, twenty-six
indole derivatives containing thiazolidine-2, 4-dione were synthesized. All compounds …
indole derivatives containing thiazolidine-2, 4-dione were synthesized. All compounds …
Bio-oriented synthesis of novel (S)-flurbiprofen clubbed hydrazone schiff's bases for diabetic management: In vitro and in silico studies
A new series of (S)-flurbiprofen derivatives 4a–4p and 5a–5n were synthesized with different
aromatic or aliphatic aldehydes and ketones to produce Schiff's bases and their structures …
aromatic or aliphatic aldehydes and ketones to produce Schiff's bases and their structures …
A facile approach synthesis of benzoylaryl benzimidazole as potential α-amylase and α-glucosidase inhibitor with antioxidant activity
LM Aroua, HR Almuhaylan, FM Alminderej… - Bioorganic …, 2021 - Elsevier
Synthetic routes to a series of benzoylarylbenzimidazol 3a-h have been derived from 3, 4-
diaminobenzophenone and an appropriate arylaldehyde in the presence of ammonium …
diaminobenzophenone and an appropriate arylaldehyde in the presence of ammonium …
α-Glucosidase inhibitors from brown rice bound phenolics extracts (BRBPE): Identification and mechanism
C Ye, R Zhang, L Dong, J Chi, F Huang, L Dong… - Food chemistry, 2022 - Elsevier
Brown rice bound phenolics extracts (BRBPE) have been reported to possess α-glucosidase
inhibitory effects, the specific enzyme inhibitors involved in this process were unknown …
inhibitory effects, the specific enzyme inhibitors involved in this process were unknown …
[HTML][HTML] Phenolics from Physalis peruviana fruits ameliorate streptozotocin-induced diabetes and diabetic nephropathy in rats via induction of autophagy and …
SM Ezzat, HMI Abdallah, NN Yassen… - Biomedicine & …, 2021 - Elsevier
The objective of our study was to evaluate the effect of Physalis peruviana L. fruits in the
management of diabetes and diabetic nephropathy in relation to its metabolic profile. In-vitro …
management of diabetes and diabetic nephropathy in relation to its metabolic profile. In-vitro …
[HTML][HTML] Evaluating the in vitro antidiabetic, antibacterial and antioxidant properties of copper (II) Schiff base complexes: An experimental and computational studies
In recent years, metal-based compounds have been explored as potential remedies for
major health issues such as diabetes, bacterial infections, and oxidative stress, which impact …
major health issues such as diabetes, bacterial infections, and oxidative stress, which impact …
Synthesis of indole derivatives as diabetics II inhibitors and enzymatic kinetics study of α-glucosidase and α-amylase along with their in-silico study
In this study, we have investigated a series of indole-based compounds for their inhibitory
study against pancreatic α-amylase and intestinal α-glucosidase activity. Inhibitors of …
study against pancreatic α-amylase and intestinal α-glucosidase activity. Inhibitors of …
[HTML][HTML] Synthesis, characterization, biological evaluation, and kinetic study of indole base sulfonamide derivatives as acetylcholinesterase inhibitors in search of …
Alzheimer is a prolonged neurodegenerative disease which degenerate the brain cells and
particularly affects the person ability to function independently. Despite of dynamic research …
particularly affects the person ability to function independently. Despite of dynamic research …