Insights into Leukemia from Single-Cell Genomics
N Sariipek, P van Galen - Annual Review of Cancer Biology, 2025 - annualreviews.org
Despite its relatively recent emergence, single-cell sequencing has cemented its place in
scientific research. It has grown exponentially in less than two decades since its start, with …
scientific research. It has grown exponentially in less than two decades since its start, with …
Genotype-immunophenotype relationships in NPM1-mutant AML clonal evolution uncovered by single cell multiomic analysis
M Drucker, D Lee, X Zhang, B Kain, M Bowman… - bioRxiv, 2024 - biorxiv.org
Acute myeloid leukemia (AML) is a multi-clonal disease, existing as a milieu of clones with
unique but related genotypes as initiating clones acquire subsequent mutations. However …
unique but related genotypes as initiating clones acquire subsequent mutations. However …
Models to study myelodysplastic syndrome and acute myeloid leukaemia
C Chao, IG Martinez, E Wagenblast - Current Opinion in Hematology - journals.lww.com
PDXs, iPSCs, and genetically engineered HSPCs are crucial models for the study of MDS
and AML. This review discusses strengths, limitations, and recent advancements of these …
and AML. This review discusses strengths, limitations, and recent advancements of these …
The crossroads of clonal evolution, differentiation hierarchy and ontogeny in leukemia development
CM Sturgeon, E Wagenblast, F Izzo… - Blood Cancer …, 2024 - aacrjournals.org
Transformative technologies to sequence tumor genomes at large scale and single-cell
resolution have exposed the repertoire of genetic alterations that are present in leukemia …
resolution have exposed the repertoire of genetic alterations that are present in leukemia …