Mitochondrial dysfunctions in T cells: focus on inflammatory bowel disease

H Lee, JH Jeon, ES Kim - Frontiers in immunology, 2023 - frontiersin.org
Mitochondria has emerged as a critical ruler of metabolic reprogramming in immune
responses and inflammation. In the context of colitogenic T cells and IBD, there has been …

Hypoxia and intestinal inflammation: common molecular mechanisms and signaling pathways

KA Dvornikova, ON Platonova, EY Bystrova - International Journal of …, 2023 - mdpi.com
The gastrointestinal tract (GI) has a unique oxygenation profile. It should be noted that the
state of hypoxia can be characteristic of both normal and pathological conditions. Hypoxia …

Relationship between hypoxic and immune pathways activation in the progression of neuroinflammation: role of HIF-1α and Th17 cells

C Arias, P Sepúlveda, RL Castillo… - International journal of …, 2023 - mdpi.com
Neuroinflammation is a common event in degenerative diseases of the central and
peripheral nervous system, triggered by alterations in the immune system or inflammatory …

Crosstalk between hypoxia-inducible factor-1α and short-chain fatty acids in inflammatory bowel disease: key clues toward unraveling the mystery

J Xiao, X Guo, Z Wang - Frontiers in Immunology, 2024 - frontiersin.org
The human intestinal tract constitutes a complex ecosystem, made up of countless gut
microbiota, metabolites, and immune cells, with hypoxia being a fundamental environmental …

Oxygen-dependent regulation of ion channels: acute responses, post-translational modification, and response to chronic hypoxia

HY Yoo, SJ Kim - Pflügers Archiv-European Journal of Physiology, 2021 - Springer
Oxygen is a vital element for the survival of cells in multicellular aerobic organisms such as
mammals. Lack of O2 availability caused by environmental or pathological conditions leads …

细胞内钾离子稳态测量技术及其调控机制研究进展.

颜芷昕, 宋娜娜, 丁小强 - Fudan University Journal of …, 2023 - search.ebscohost.com
钾离子在细胞内液, 细胞外液及亚细胞结构中的分布处于动态平衡, 它是细胞内液含量最丰富的
阳离子, 在细胞外液含量却很少; 在亚细胞结构中, 钾离子在胞核的浓度最高, 细胞基质, 线粒体 …

Network pharmacology identifies the mechanisms of action of Tongxie Anchang decoction in the treatment of irritable bowel syndrome with diarrhea predominant

X Tan, W Pei, C Xie, Z Wang, T Mao… - Evidence‐Based …, 2020 - Wiley Online Library
Aim. This study aims to uncover the pharmacological mechanism of Tongxie Anchang
Decoction (TXACD), a new and effective traditional Chinese medicine (TCM) prescription …

Effects of ion-transporting proteins on the digestive system under hypoxia

Y Xiang, D Fan, Q An, T Zhang, X Wu, J Ding… - Frontiers in …, 2022 - frontiersin.org
Hypoxia refers to a state of oxygen limitation, which mainly mediates pathological processes
in the human body and participates in the regulation of normal physiological processes. In …