Meningiomas are the most common intracranial tumor, making up more than a third of all
primary central nervous system (CNS) tumors. They are mostly benign tumors that can be …

Background: Previous guidelines for the management of thyroid nodules and cancers were
geared toward adults. Compared with thyroid neoplasms in adults, however, those in the …

Objective: To develop evidence-based recommendations for safe, effective, and appropriate
thyroidectomy. Background: Surgical management of thyroid disease has evolved …

For the past 30 years, improvements in the survival of patients with osteosarcoma have been
mostly incremental. Despite evidence of genomic instability and a high frequency of …

Aging is the inevitable time-dependent decline in physiological organ function and is a
major risk factor for cancer development. Due to advances in health care, hygiene control …

RecQ helicases are an important family of genome surveillance proteins conserved from
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …

Human colorectal cancer cell lines are used widely to investigate tumor biology,
experimental therapy, and biomarkers. However, to what extent these established cell lines …

Werner syndrome (WS) is a prototypical segmental progeroid syndrome characterized by
multiple features consistent with accelerated aging. It is caused by null mutations of the …

Approximately 10% of melanoma cases report a relative affected with melanoma, and a
positive family history is associated with an increased risk of developing melanoma …

Helicases have major roles in genome maintenance by unwinding structured nucleic acids.
Their prominence is marked by various cancers and genetic disorders that are linked to …