A significant mortality rate is associated with oral cancer, particularly in cases of late-stage
diagnosis. Since the last decades, oral cancer survival rates have only gradually improved …

Abstract High-dose methotrexate (HDMTX), defined as a dose higher than 500 mg/m2, is
used to treat a range of adult and childhood cancers. Although HDMTX is safely …

Radiation-induced oral mucositis (RIOM) is a major dose-limiting toxicity in head and neck
cancer patients. It is a normal tissue injury caused by radiation/radiotherapy (RT), which has …

Mucositis is a common complication of chemotherapy, radiotherapy and targeted agents. It
often affects compliance to anticancer therapies as it frequently causes schedule delays …

Oral and gastrointestinal mucositis is a toxicity of many forms of radiotherapy and
chemotherapy. It has a significant impact on health, quality of life and economic outcomes …

The lack of therapy and the failure of existing therapy has been a challenge for clinicians in
treating various cancers. Doxorubicin, 5-fluorouracil, cisplatin, and paclitaxel are the first-line …

In addition to anti-tumor effects, ionizing radiation causes damage in normal tissues located
in the radiation portals. Oral complications of radiotherapy in the head and neck region are …

The history of mucositis is as old as radiation-and chemotherapy. Despite being regularly
reported and documented as one of the worst side effects of cancer therapy, relatively little …

Background Oral mucositis is a complication of intensive chemotherapy and radiotherapy
with no effective treatment. We tested the ability of palifermin (recombinant human …

The term mucositis is coined to describe the adverse effects of radiation and chemotherapy
treatments. Mucositis is one of the most common adverse reactions encountered in radiation …