In this review, we discuss the connections between mitochondria and the gut microbiome
provided by reactive oxygen species (ROS). We examine the mitochondrion as an …

Mitochondria are key to energy conversion in virtually all eukaryotes. Intriguingly, despite
billions of years of evolution inside the eukaryote, mitochondria have retained their own …

Triglycerides are the major form of stored fat in all animals. One important determinant of
whole-body fat storage is whether an animal is male or female. Here, we use Drosophila, an …

Incompatibilities between mitochondrial and nuclear genes can perturb respiration,
biosynthesis, signaling and gene expression. Here we investigate whether mild mitonuclear …

Evolutionary theory proposes that maternal inheritance of mitochondria will facilitate the
accumulation of mitochondrial DNA (mtDNA) mutations that are harmful to males but benign …

Diet may be modified seasonally or by biogeographic, demographic or cultural shifts. It can
differentially influence mitochondrial bioenergetics, retrograde signalling to the nuclear …

Environmental stresses such as extreme temperatures, dehydration and food deprivation
may have distinct consequences for different age-classes and for males and females across …

Highlights•Drosophila exhibits qualitative and quantitative sexual dimorphisms in
behavior.•A class of sexually dimorphic neurons may contain multiple subclasses.•Sex …

Maternal inheritance of mitochondrial DNA (mtDNA) renders selection blind to mutations
whose effects are limited to males. Evolutionary theory predicts this will lead to the …

Impaired mitochondrial function can lead to senescence and the ageing phenotype. Theory
predicts degenerative ageing phenotypes and mitochondrial pathologies may occur more …