Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and
type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic …

Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Insulin resistance is a multi-faceted disruption of the communication between insulin and the
interior of a target cell. The underlying cause of insulin resistance appears to be …

The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

Diets rich in saturated fat produce inflammation, gliosis, and neuronal stress in the
mediobasal hypothalamus (MBH). Here, we show that microglia mediate this process and its …

Accumulated evidence from genetic animal models suggests that the brain, particularly the
hypothalamus, has a key role in the homeostatic regulation of energy and glucose …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

The capacity to adjust food intake in response to changing energy requirements is essential
for survival. Recent progress has provided an insight into the molecular, cellular and …

Dieting is the most common approach to losing weight for the majority of obese and
overweight individuals. Restricting intake leads to weight loss in the short term, but, by itself …

Carnitine is a conditionally essential nutrient that plays a vital role in energy production and
fatty acid metabolism. Vegetarians possess a greater bioavailability than meat eaters …