MMP‐9 in translation: from molecule to brain physiology, pathology, and therapy

B Vafadari, A Salamian… - Journal of …, 2016 - Wiley Online Library
Abstract Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …

Stress-related dysfunction of adult hippocampal neurogenesis—an attempt for understanding resilience?

J Leschik, B Lutz, A Gentile - International Journal of Molecular Sciences, 2021 - mdpi.com
Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …

[PDF][PDF] Bidirectional Mendelian randomization and multiphenotype GWAS show causality and shared pathophysiology between depression and type 2 diabetes

JG Maina, Z Balkhiyarova, A Nouwen, I Pupko… - Diabetes …, 2023 - Am Diabetes Assoc
OBJECTIVE Depression is a common comorbidity of type 2 diabetes. We assessed the
causal relationships and shared genetics between them. RESEARCH DESIGN AND …

Brain-derived neurotrophic factor Val66Met human polymorphism impairs the beneficial exercise-induced neurobiological changes in mice

A Ieraci, AI Madaio, A Mallei, FS Lee… - …, 2016 - nature.com
Several studies have shown that exercise improves cognitive functions and emotional
behaviors. Positive effects of exercise have been associated with enhanced brain plasticity …

Understanding the effects of chronic benzodiazepine use in depression: a focus on neuropharmacology

B Lim, BA Sproule, Z Zahra, N Sunderji… - International clinical …, 2020 - journals.lww.com
Benzodiazepines are frequently prescribed on an ongoing basis to individuals with
depression, mainly to alleviate anxiety or insomnia, despite current guideline …

Role of adult hippocampal neurogenesis in cognition in physiology and disease: pharmacological targets and biomarkers

V Costa, S Lugert, R Jagasia - Cognitive enhancement, 2015 - Springer
Adult hippocampal neurogenesis is a remarkable form of brain structural plasticity by which
new functional neurons are generated from adult neural stem cells/precursors. Although the …

Boosting neurogenesis in the adult hippocampus using antidepressants and mesenchymal stem cells

M Kot, PK Neglur, A Pietraszewska, L Buzanska - Cells, 2022 - mdpi.com
The hippocampus is one of the few privileged regions (neural stem cell niche) of the brain,
where neural stem cells differentiate into new neurons throughout adulthood. However …

Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity

CM Grimm, S Aksamaz, S Schulz, J Teutsch… - Translational …, 2018 - nature.com
Elevated activity at the output stage of the anterior hippocampus has been described as a
physiological endophenotype of schizophrenia, and its development maps onto the …

Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors

L Garrett, J Zhang, A Zimprich… - Frontiers in Behavioral …, 2015 - frontiersin.org
Adult neurogenesis occurs in the adult mammalian subventricular zone (SVZ) along the
walls of the lateral ventricles and the subgranular zone (SGZ) of the hippocampal dentate …

Insights into the biology and therapeutic applications of neural stem cells

L Harris, O Zalucki, M Piper, JIT Heng - Stem cells international, 2016 - Wiley Online Library
The cerebral cortex is essential for our higher cognitive functions and emotional reasoning.
Arguably, this brain structure is the distinguishing feature of our species, and yet our …