MMP‐9 in translation: from molecule to brain physiology, pathology, and therapy
B Vafadari, A Salamian… - Journal of …, 2016 - Wiley Online Library
Abstract Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …
Stress-related dysfunction of adult hippocampal neurogenesis—an attempt for understanding resilience?
Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …
[PDF][PDF] Bidirectional Mendelian randomization and multiphenotype GWAS show causality and shared pathophysiology between depression and type 2 diabetes
OBJECTIVE Depression is a common comorbidity of type 2 diabetes. We assessed the
causal relationships and shared genetics between them. RESEARCH DESIGN AND …
causal relationships and shared genetics between them. RESEARCH DESIGN AND …
Brain-derived neurotrophic factor Val66Met human polymorphism impairs the beneficial exercise-induced neurobiological changes in mice
A Ieraci, AI Madaio, A Mallei, FS Lee… - …, 2016 - nature.com
Several studies have shown that exercise improves cognitive functions and emotional
behaviors. Positive effects of exercise have been associated with enhanced brain plasticity …
behaviors. Positive effects of exercise have been associated with enhanced brain plasticity …
Understanding the effects of chronic benzodiazepine use in depression: a focus on neuropharmacology
Benzodiazepines are frequently prescribed on an ongoing basis to individuals with
depression, mainly to alleviate anxiety or insomnia, despite current guideline …
depression, mainly to alleviate anxiety or insomnia, despite current guideline …
Role of adult hippocampal neurogenesis in cognition in physiology and disease: pharmacological targets and biomarkers
V Costa, S Lugert, R Jagasia - Cognitive enhancement, 2015 - Springer
Adult hippocampal neurogenesis is a remarkable form of brain structural plasticity by which
new functional neurons are generated from adult neural stem cells/precursors. Although the …
new functional neurons are generated from adult neural stem cells/precursors. Although the …
Boosting neurogenesis in the adult hippocampus using antidepressants and mesenchymal stem cells
M Kot, PK Neglur, A Pietraszewska, L Buzanska - Cells, 2022 - mdpi.com
The hippocampus is one of the few privileged regions (neural stem cell niche) of the brain,
where neural stem cells differentiate into new neurons throughout adulthood. However …
where neural stem cells differentiate into new neurons throughout adulthood. However …
Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity
CM Grimm, S Aksamaz, S Schulz, J Teutsch… - Translational …, 2018 - nature.com
Elevated activity at the output stage of the anterior hippocampus has been described as a
physiological endophenotype of schizophrenia, and its development maps onto the …
physiological endophenotype of schizophrenia, and its development maps onto the …
Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors
L Garrett, J Zhang, A Zimprich… - Frontiers in Behavioral …, 2015 - frontiersin.org
Adult neurogenesis occurs in the adult mammalian subventricular zone (SVZ) along the
walls of the lateral ventricles and the subgranular zone (SGZ) of the hippocampal dentate …
walls of the lateral ventricles and the subgranular zone (SGZ) of the hippocampal dentate …
Insights into the biology and therapeutic applications of neural stem cells
L Harris, O Zalucki, M Piper, JIT Heng - Stem cells international, 2016 - Wiley Online Library
The cerebral cortex is essential for our higher cognitive functions and emotional reasoning.
Arguably, this brain structure is the distinguishing feature of our species, and yet our …
Arguably, this brain structure is the distinguishing feature of our species, and yet our …