Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that
prevent the activation of DNA damage response and repair pathways. Numerous factors …

Regulator of telomere elongation 1 (RTEL1) is known as a DNA helicase that is important for
telomeres and genome integrity. However, the diverse phenotypes of RTEL1 dysfunction …

Older patients with acute myeloid leukemia (AML) have high relapse risk and poor survival
after allogeneic hematopoietic cell transplantation (HCT). Younger patients may receive …

Aplastic anemia (AA) is rare disorder of bone marrow failure which if severe and not
appropriately treated is highly fatal. AA is characterized by morphologic marrow features …

Cellular gene expression changes throughout a dynamic biological process, such as
differentiation. Pseudotimes estimate cells' progress along a dynamic process based on …

Germline pathogenic TERT variants are associated with short telomeres and an increased
risk of developing myelodysplastic syndrome (MDS) among patients with a telomere biology …

Telomeres are nucleoprotein structures at the end of chromosomes. The telomerase
complex, constituted of the catalytic subunit TERT, the RNA matrix h TR and several …

Hypoplastic myelodysplastic syndrome (hMDS) and aplastic anemia (AA) are rare
hematopoietic disorders characterized by pancytopenia with hypoplastic bone marrow (BM) …

Regulator of telomere length 1 (RTEL1) mutations have been evidenced in 5–9% of familial
pulmonary fibrosis; however, the phenotype of patients with interstitial lung disease (ILD) …

Purpose The acquisition of pathogenic variants in the TERT promoter (TERTp) region is a
mechanism of tumorigenesis. In nonmalignant diseases, TERTp variants have been …