Advancing toxicity studies of per-and poly-fluoroalkyl substances (pfass) through machine learning: Models, mechanisms, and future directions

L Meng, B Zhou, H Liu, Y Chen, R Yuan, Z Chen… - Science of The Total …, 2024 - Elsevier
Perfluorinated and perfluoroalkyl substances (PFASs), encompassing a vast array of
isomeric chemicals, are recognized as typical emerging contaminants with direct or potential …

The New Paradigm in Animal Testing–“3Rs Alternatives”

WT Poh, J Stanslas - Regulatory Toxicology and Pharmacology, 2024 - Elsevier
Regulatory studies have revolutionised over time. Today, the focus has shifted from animal
toxicity testing to non-animal for regulatory safety testing. This move is in line with the …

Perceptions of 3R implementation in European animal research: A systematic review, meta-analysis, and meta-synthesis of barriers and facilitators

E Louis-Maerten, A Milford, DM Shaw, LD Geneviève… - Plos one, 2024 - journals.plos.org
Objectives The purpose of this systematic review was to examine how the scientific
community in Europe that is involved with research with animals perceives and experiences …

In vitro 3D skin culture and its sustainability in toxicology: a narrative review

S Masri, MB Fauzi, NF Rajab, WH Lee… - Artificial Cells …, 2024 - Taylor & Francis
In current toxicological research, 2D cell cultures and animal models are well-accepted and
commonly employed methods. However, these approaches have many drawbacks and are …

In vivo animal models development and their limitations for brain research

SV Mangrulkar, SV Dabhekar, P Neje… - … of Nanocarriers in Brain …, 2024 - Springer
In vivo animal models play a crucial role in advancing our understanding of the complexities
of the brain and neurological disorders. This abstract explores the processes involved in the …

Why Do I Choose an Animal Model or an Alternative Method in Basic and Preclinical Biomedical Research? A Spectrum of Ethically Relevant Reasons and Their …

H Kahrass, I Pietschmann, M Mertz - Animals, 2024 - mdpi.com
Simple Summary Some basic and preclinical biomedical research models require the use of
animals. It is not always clear which model is best suited to a project—animals or models …

Cerebrolysin Induces Motor Recovery Along with Plastic Changes in Motoneurons and an Increase in GAP43 Protein in the Ventral Spinal Cord Following a Kainic …

NI Martínez-Torres, J Cárdenas-Bedoya… - Neurochemical …, 2025 - Springer
Lesions in the motor cortex induced by contusions or pathological insults can exert the
degeneration of afferent neurons lying distal to these lesions. Axon degeneration and …

Measurement of compassion fatigue in animal health care professionals: a systematic review of available instruments and their content validity

MTN Noe, Y Baysal, A Masserey, S Hartnack… - Frontiers in Veterinary …, 2024 - frontiersin.org
Introduction Compassion fatigue (CF) refers to emotional or physical exhaustion and
emotional reactions resulting from prolonged exposure to traumatic events, commonly …

Intuitive toxicology in the 21st century—Bridging the perspectives of the public and risk assessors in Europe

A Bearth, N Roth, MF Wilks, M Siegrist - Risk analysis, 2024 - Wiley Online Library
Three decades ago, several articles on the subjectivity in chemical risk judgments (ie,
labeled “intuitive toxicology”) measured the divide between the public and toxicologists with …

Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals

AL Roe, J Krzykwa, AI Calderón… - Journal of Dietary …, 2024 - Taylor & Francis
Botanical supplements, herbal remedies, and plant-derived products are used globally.
However, botanical dietary supplements are rarely subjected to robust safety testing unless …