Advancing toxicity studies of per-and poly-fluoroalkyl substances (pfass) through machine learning: Models, mechanisms, and future directions
L Meng, B Zhou, H Liu, Y Chen, R Yuan, Z Chen… - Science of The Total …, 2024 - Elsevier
Perfluorinated and perfluoroalkyl substances (PFASs), encompassing a vast array of
isomeric chemicals, are recognized as typical emerging contaminants with direct or potential …
isomeric chemicals, are recognized as typical emerging contaminants with direct or potential …
The New Paradigm in Animal Testing–“3Rs Alternatives”
WT Poh, J Stanslas - Regulatory Toxicology and Pharmacology, 2024 - Elsevier
Regulatory studies have revolutionised over time. Today, the focus has shifted from animal
toxicity testing to non-animal for regulatory safety testing. This move is in line with the …
toxicity testing to non-animal for regulatory safety testing. This move is in line with the …
Perceptions of 3R implementation in European animal research: A systematic review, meta-analysis, and meta-synthesis of barriers and facilitators
E Louis-Maerten, A Milford, DM Shaw, LD Geneviève… - Plos one, 2024 - journals.plos.org
Objectives The purpose of this systematic review was to examine how the scientific
community in Europe that is involved with research with animals perceives and experiences …
community in Europe that is involved with research with animals perceives and experiences …
In vitro 3D skin culture and its sustainability in toxicology: a narrative review
In current toxicological research, 2D cell cultures and animal models are well-accepted and
commonly employed methods. However, these approaches have many drawbacks and are …
commonly employed methods. However, these approaches have many drawbacks and are …
In vivo animal models development and their limitations for brain research
SV Mangrulkar, SV Dabhekar, P Neje… - … of Nanocarriers in Brain …, 2024 - Springer
In vivo animal models play a crucial role in advancing our understanding of the complexities
of the brain and neurological disorders. This abstract explores the processes involved in the …
of the brain and neurological disorders. This abstract explores the processes involved in the …
Why Do I Choose an Animal Model or an Alternative Method in Basic and Preclinical Biomedical Research? A Spectrum of Ethically Relevant Reasons and Their …
H Kahrass, I Pietschmann, M Mertz - Animals, 2024 - mdpi.com
Simple Summary Some basic and preclinical biomedical research models require the use of
animals. It is not always clear which model is best suited to a project—animals or models …
animals. It is not always clear which model is best suited to a project—animals or models …
Cerebrolysin Induces Motor Recovery Along with Plastic Changes in Motoneurons and an Increase in GAP43 Protein in the Ventral Spinal Cord Following a Kainic …
NI Martínez-Torres, J Cárdenas-Bedoya… - Neurochemical …, 2025 - Springer
Lesions in the motor cortex induced by contusions or pathological insults can exert the
degeneration of afferent neurons lying distal to these lesions. Axon degeneration and …
degeneration of afferent neurons lying distal to these lesions. Axon degeneration and …
Measurement of compassion fatigue in animal health care professionals: a systematic review of available instruments and their content validity
MTN Noe, Y Baysal, A Masserey, S Hartnack… - Frontiers in Veterinary …, 2024 - frontiersin.org
Introduction Compassion fatigue (CF) refers to emotional or physical exhaustion and
emotional reactions resulting from prolonged exposure to traumatic events, commonly …
emotional reactions resulting from prolonged exposure to traumatic events, commonly …
Intuitive toxicology in the 21st century—Bridging the perspectives of the public and risk assessors in Europe
Three decades ago, several articles on the subjectivity in chemical risk judgments (ie,
labeled “intuitive toxicology”) measured the divide between the public and toxicologists with …
labeled “intuitive toxicology”) measured the divide between the public and toxicologists with …
Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals
AL Roe, J Krzykwa, AI Calderón… - Journal of Dietary …, 2024 - Taylor & Francis
Botanical supplements, herbal remedies, and plant-derived products are used globally.
However, botanical dietary supplements are rarely subjected to robust safety testing unless …
However, botanical dietary supplements are rarely subjected to robust safety testing unless …