Ovarian cancer is an aggressive disease that is frequently detected at advanced stages and
is initially very responsive to platinum-based chemotherapy. However, the majority of …

Melanomas arising in the uveal tract of the eye are a rare form of the disease with a biology
and clinical phenotype distinct from their more common cutaneous counterparts. Treatment …

Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein
that primarily regulates adhesion signalling and cell migration, but FAK can also promote …

Simple Summary The development of uveal melanoma is a multifactorial and multi-step
process, in which specific and recurrent mutations arise early. Among the recurrently …

Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …

Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

Androgen receptor (AR) signaling inhibitors provide limited survival benefits to patients with
prostate cancer (PCa), and worse, few feasible genomic lesions restrict targeted treatment to …

Simple Summary Uveal melanoma is the most common primary intraocular malignancy in
adults. Unfortunately, metastasis develops in up to 50% of cases and outcomes are poor for …

Uveal melanoma (UM) is a rare cancer arising from melanocytes in the uveal tract of the eye.
Despite effective primary treatment, there is no approved therapy for metastatic UM and …

Melanoma is the deadliest form of skin cancer. Although targeted therapies and
immunotherapies have revolutionized the treatment of metastatic melanoma, most patients …