Innovation has frequently been described as the key to drug discovery. However, in the daily
routine, medicinal chemists often tend to stick to the functional groups and structural …

Sulfoximines are widely used as medicines, agricultural chemicals, chiral precursors, and
chiral ligands in asymmetric synthesis, as well as pivotal intermediates for the construction of …

Sulfoximines have been largely disregarded in medicinal chemistry for a long time.
However, recently, they have risen to the apparent level of stardom on the drug discovery …

Phosphine oxides and related phosphorus-containing functional groups such as
phosphonates and phosphinates are established structural motifs that are still …

Transition metal‐catalyzed enantioselective C− H activation of prochiral sulfoximines for non‐
annulated products remains a formidable challenge. We herein report iridium‐catalyzed …

An efficient kinetic resolution of sulfoximines with enals was realized using chiral N-
heterocyclic carbene (NHC) catalysts. The stereoselective amidation proceeds without …

A metal-, base-, and additive-free N-acylation of sulfoximines was developed under mild
conditions using organic photoredox catalyst. This green strategy featured broad substrate …

Innovation ist häufig als der Schlüssel zur Wirkstoff‐Findung beschrieben worden. Doch in
der täglichen Routine neigen Medizinalchemiker dazu, nur das Instrumentarium der …

A general method for the N‐alkylation of NH‐sulfoximines and NH‐sulfondiimines has been
developed, employing alkyl bromides with KOH in DMSO at room temperature. A variety of …

Transfer of electrophilic NH to sulfides and a subsequent sulfimine‐promoted fast O transfer
have been achieved in a one‐pot process unprecedentedly for the preparation of …