Iron and sphingolipids as common players of (Mal) adaptation to hypoxia in pulmonary diseases
S Ottolenghi, A Zulueta, A Caretti - International Journal of Molecular …, 2020 - mdpi.com
Hypoxia, or lack of oxygen, can occur in both physiological (high altitude) and pathological
conditions (respiratory diseases). In this narrative review, we introduce high altitude …
conditions (respiratory diseases). In this narrative review, we introduce high altitude …
Sphingosine 1-phosphate in sepsis and beyond: its role in disease tolerance and host defense and the impact of carrier molecules
AC Ziegler, T Müller, MH Gräler - Cellular Signalling, 2021 - Elsevier
Abstract Sphingosine 1-phosphate (S1P) is an important immune modulator responsible for
physiological cellular responses like lymphocyte development and function, positioning and …
physiological cellular responses like lymphocyte development and function, positioning and …
Curcumin prophylaxis refurbishes alveolar epithelial barrier integrity and alveolar fluid clearance under hypoxia
M Titto, T Ankit, B Saumya, AK Gausal… - Respiratory physiology & …, 2020 - Elsevier
We have studied the prophylactic efficacy of curcumin to ameliorate the impairment of tight
junction protein integrity and fluid clearance in lungs of rats under hypoxia. A549 cells …
junction protein integrity and fluid clearance in lungs of rats under hypoxia. A549 cells …
Joint neutron crystallographic and NMR solution studies of Tyr residue ionization and hydrogen bonding: Implications for enzyme-mediated proton transfer
R Michalczyk, CJ Unkefer, JP Bacik… - Proceedings of the …, 2015 - National Acad Sciences
Human carbonic anhydrase II (HCA II) uses a Zn-bound OH−/H2O mechanism to catalyze
the reversible hydration of CO2. This catalysis also involves a separate proton transfer step …
the reversible hydration of CO2. This catalysis also involves a separate proton transfer step …
Preventive preclinical efficacy of intravenously administered sphingosine-1-phosphate (S1P) in strengthening hypoxia adaptive responses to acute and sub-chronic …
Abstract Sphingosine-1-phosphate (S1P) is emerging as a hypoxia responsive bio-lipid;
systemically raised levels of S1P are proposed to have potential hypoxia pre-conditioning …
systemically raised levels of S1P are proposed to have potential hypoxia pre-conditioning …
Three plasma metabolite signatures for diagnosing high altitude pulmonary edema
L Guo, G Tan, P Liu, H Li, L Tang, L Huang, Q Ren - Scientific reports, 2015 - nature.com
High-altitude pulmonary edema (HAPE) is a potentially fatal condition, occurring at altitudes
greater than 3,000 m and affecting rapidly ascending, non-acclimatized healthy individuals …
greater than 3,000 m and affecting rapidly ascending, non-acclimatized healthy individuals …
Modulating effects of preconditioning exercise in the expression of ET-1 and BNP via HIF-1α in ischemically injured brain
H Wang, F Niu, W Fan, J Shi, J Zhang, B Li - Metabolic Brain Disease, 2019 - Springer
It is well-known that in ischemia-induced hypoxia, hypoxia-inducible factor-1α (HIF-1α) is
critical in triggering expression of its downstream target genes to produce several products …
critical in triggering expression of its downstream target genes to produce several products …
Hypobaric hypoxia induced renal damage is mediated by altering redox pathway
V Chhabra, AS Anand, AK Baidya, SM Malik, E Kohli… - PloS one, 2018 - journals.plos.org
Systemic hypobaric hypoxia is reported to cause renal damage; nevertheless the exact
pathophysiological mechanisms are not completely understood. Therefore, the present …
pathophysiological mechanisms are not completely understood. Therefore, the present …
Quercetin: a savior of alveolar barrier integrity under hypoxic microenvironment
High altitude pulmonary edema (HAPE) is generally characterized by the loss of alveolar
epithelial barrier integrity. The current study was undertaken to assess the noninvasive …
epithelial barrier integrity. The current study was undertaken to assess the noninvasive …
S1P prophylaxis mitigates acute hypobaric hypoxia‐induced molecular, biochemical, and metabolic disturbances: A preclinical report
Abstract Sphingosine‐1‐phosphate (S1P) is emerging to have hypoxic preconditioning
potential in various preclinical studies. The study aims to evaluate the preclinical …
potential in various preclinical studies. The study aims to evaluate the preclinical …