Tyrosine kinase gene rearrangements in epithelial malignancies

AT Shaw, PP Hsu, MM Awad, JA Engelman - Nature reviews Cancer, 2013 - nature.com
Chromosomal rearrangements that lead to oncogenic kinase activation are observed in
many epithelial cancers. These cancers express activated fusion kinases that drive the …

Occupational and environmental causes of lung cancer

RW Field, BL Withers - Clinics in chest medicine, 2012 - chestmed.theclinics.com
Although lung cancer incidence rates started to slowly decrease for men in the 1980s
followed by declining incidence rates for women in the late 1990s, 1 lung and bronchus …

ICRP publication 147: use of dose quantities in radiological protection

JD Harrison, M Balonov, F Bochud… - Annals of the …, 2021 - journals.sagepub.com
The central dose quantities used in radiological protection are absorbed dose, equivalent
dose, and effective dose. The concept of effective dose was developed by the International …

Identification of KIF5B-RET and GOPC-ROS1 Fusions in Lung Adenocarcinomas through a Comprehensive mRNA-Based Screen for Tyrosine Kinase Fusions

Y Suehara, M Arcila, L Wang, A Hasanovic, D Ang… - Clinical cancer …, 2012 - AACR
Background: The mutually exclusive pattern of the major driver oncogenes in lung cancer
suggests that other mutually exclusive oncogenes exist. We conducted a systematic search …

Recent aspects of uranium toxicology in medical geology

G Bjørklund, OA Christophersen, S Chirumbolo… - Environmental …, 2017 - Elsevier
Uranium (U) is a chemo-toxic, radiotoxic and even a carcinogenic element. Due to its
radioactivity, the effects of U on humans health have been extensively investigated …

Mortality analyses in the updated French cohort of uranium miners (1946–2007)

E Rage, S Caër-Lorho, D Drubay, S Ancelet… - International archives of …, 2015 - Springer
Purpose The objectives are to analyze mortality risks in the extended follow-up of the French
uranium miners' cohort and to examine their potential relation to occupational exposure to …

Mortality among uranium miners in North America and Europe: the pooled uranium miners analysis (PUMA)

DB Richardson, E Rage, PA Demers… - International journal …, 2021 - academic.oup.com
Abstract Background The Pooled Uranium Miners Analysis (PUMA) study draws together
information from cohorts of uranium miners from Canada, the Czech Republic, France …

Risk of lung cancer mortality in nuclear workers from internal exposure to alpha particle-emitting radionuclides

J Grellier, W Atkinson, P Bérard, D Bingham… - …, 2017 - journals.lww.com
Background: Carcinogenic risks of internal exposures to alpha-emitters (except radon) are
poorly understood. Since exposure to alpha particles—particularly through inhalation …

Comparing the metal concentration in the hair of cancer patients and healthy people living in the Malwa region of Punjab, India

E Blaurock-Busch, YM Busch… - Clinical Medicine …, 2014 - journals.sagepub.com
The cancer prevalence in the Malwa region of Punjab (1089/million/year) is much higher
than the national average cancer prevalence in India (800/million/year). The participants in …

Low radon exposures and lung cancer risk: joint analysis of the Czech, French, and Beaverlodge cohorts of uranium miners

RSD Lane, L Tomášek, LB Zablotska, E Rage… - International archives of …, 2019 - Springer
It is well established that high radon exposures increase the risk of lung cancer mortality.
The effects of low occupational exposures and the factors that confound and modify this risk …