Glioblastoma multiform (GBM) is the most common malignant glioma of all the brain tumors
and currently effective treatment options are still lacking. GBM is frequently accompanied …

Reactive oxygen species (ROS) and their products are components of cell signaling
pathways and play important roles in cellular physiology and pathophysiology. Under …

Osteosarcoma (OS) is the most common nonhematologic bone malignancy in children and
adolescents. Despite the advances of adjuvant chemotherapy and significant improvement …

Neutrophils are known to extrude decondensed chromatin, thus forming NETs (neutrophil
extracellular traps). These structures immobilize pathogens, thereby preventing their …

It is well established that the PI3K pathway plays a central role in various cellular processes
that can contribute to the malignant phenotype. Accordingly, pharmacological inhibition of …

Abstract The phosphoinositide 3-kinase-AKT-mammalian target of rapamycin (PI3K-AKT-
mTOR) pathway is a frequently hyperactivated pathway in cancer and is important for tumor …

The phosphatidylinositol 3 kinase (PI3K) pathway is one of the major pathways modulating
cell growth, proliferation, metabolism, survival, and angiogenesis. Hyperactivation of this …

Abstract The PI3K-Akt pathway is a vital regulator of cell proliferation and survival.
Alterations in the PIK3CA gene that lead to enhanced PI3K kinase activity have been …

Abstract The phosphatidylinositiol 3-kinase (PI3K), AKT, mammalian target of rapamycin
(mTOR) signaling pathway (PI3K/AKT/mTOR) is frequently dysregulated in disorders of cell …

Inhibition of the survival kinase Akt can trigger apoptosis, and also has been found to
activate autophagy, which may confound tumor attack. In this study, we investigated …