The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and
parasitic pathogens. Recognition of these unique glycans by the human immune system …

Recent technological advances in glycobiology and glycochemistry are paving the way for a
new era in carbohydrate vaccine design. This is enabling greater efficiency in the …

Our understanding of the different glycoconjugates present on cells, proteins and entire
organisms is lagging far behind advances in genomics and proteomics. Carbohydrate …

Carbohydrates have been shown to play important roles in biological processes. The pace
of development in carbohydrate research is, however, relatively slow due to the problems …

Virus-like particles (VLPs) are highly organised spheres that self-assemble from virus-
derived structural antigens. These stable and versatile subviral particles possess excellent …

Peptides and oligonucleotides are prepared by automated synthesizers that can be
operated by non-specialists. Carbohydrates have been hard to assemble, but the increasing …

Carbohydrate antigens have shown promise as important targets for developing effective
vaccines and pathogen detection strategies. Modifying purified microbial glycans through …

Access to synthetic carbohydrates is an urgent need for the development of carbohydrate-
based drugs, vaccines, adjuvants as well as novel drug delivery systems. Besides traditional …

Carbohydrates: A Frontier in Medicinal Chemistry | Journal of Medicinal Chemistry ACS
ACS Publications C&EN CAS Find my institution Log In Journal of Medicinal Chemistry ACS …

Despite the enormous progress achieved by modern medicine, numerous diseases still
have a profound impact on public health. Infectious diseases caused by a variety of …