Triple-negative breast cancer (TNBC) encompasses a heterogeneous group of
fundamentally different diseases with different histologic, genomic, and immunologic …

The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in
organ development, epithelial homeostasis, tissue regeneration, wound healing and …

Altered metabolism is a hallmark of cancer, and the reprogramming of energy metabolism
has historically been considered a general phenomenon of tumors. It is well recognized that …

Cervical squamous cell carcinoma (CESC) is a prototypical human cancer with well-
characterized pathological stages of initiation and progression. However, high-resolution …

Molecular alterations in cancer can cause phenotypic changes in tumor cells and their
microenvironment. Routine histopathology tissue slides, which are ubiquitously available …

Abstract Models that recapitulate the complexity of human tumors are urgently needed to
develop more effective cancer therapies. We report a bank of human patient-derived …

Understanding the inner workings of complex machine learning models is a long-standing
problem and most recent research has focused on local interpretability. To assess the role of …

Researchers have proposed a wide variety of model explanation approaches, but it remains
unclear how most methods are related or when one method is preferable to another. We …

We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …

Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression
and they play fundamental roles in immune regulation. Here we introduce an integrated …