In recent years, great progress has been made in elucidating the progenitor-cell hierarchy of
the myeloid lineage. Transcription factors have been shown to be key determinants in the …

Acute lymphoblastic leukaemia (ALL) occurs at all ages but is the most common cancer of
childhood. The current treatment of paediatric ALL is highly successful with up to 90 …

We report 2 novel, cryptic chromosomal abnormalities in precursor B-cell acute
lymphoblastic leukemia (BCP-ALL): a translocation, either t (X; 14)(p22; q32) or t (Y; …

Cytogenetics has determined the incidence and prognostic significance of chromosomal
abnormalities in acute lymphoblastic leukaemia (ALL). The development of fluorescence in …

While much is known about aberrant pathways affecting cell growth and apoptosis, our
understanding of another critical step of neoplastic transformation, differentiation arrest …

The pathways by which oncogenes, such as MLL-AF9, initiate transformation and leukemia
in humans and mice are incompletely defined. In a study of target cells and oncogene …

In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent
childhood hematological malignancy, as well as the leading cause of childhood cancer …

Energetically speaking, ribosome biogenesis is by far the most costly process of the cell and,
therefore, must be highly regulated in order to avoid unnecessary energy expenditure. Not …

CCAAT enhancer-binding protein (CEBP) transcription factors play pivotal roles in
proliferation and differentiation, including suppression of myeloid leukemogenesis …

Gene expression profiling of acute myeloid leukemia (AML) allows the discovery of
previously unrecognized molecular entities. Here, we identified a specific subgroup of AML …