The shape of the force-velocity (FV) relationship has important implications for different
aspects of muscle physiology, such as muscle efficiency and fatigue, the understanding of …

Force generation in striated muscle is primarily controlled by structural changes in the actin-
containing thin filaments triggered by an increase in intracellular calcium concentration …

The general structural features of the motor region of myosin superfamily members are now
well established, as is a subset of the structural and kinetic transitions of the actin-myosin …

The mammalian heart pumps blood through the vessels, maintaining the dynamic
equilibrium in a circulatory system driven by two pumps in series. This vital function is based …

Muscle contraction is commonly associated with the cross-bridge and sliding filament
theories, which have received strong support from experiments conducted over the years in …

In this paper we report, clarify and broaden various recent efforts to complement the
chemistry-centered models of force generation in (skeletal) muscles by mechanics-centered …

Muscles convert energy from ATP into useful work, which can be used to move limbs and to
transport ions across membranes. The energy not converted into work appears as heat. At …

Myosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis
into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range …

Following an active lengthening contraction while maintaining activation constant, isometric
force is elevated above that of a purely isometric contraction at the same final muscle length …

Work is generated in muscle by myosin crossbridges during their interaction with the actin
filament. The energy from which the work is produced is the free energy change of ATP …