Brief update on endocytosis of nanomedicines
The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …
Rekindling RNAi therapy: materials design requirements for in vivo siRNA delivery
With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference
(RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …
(RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …
Drug delivery to the brain across the blood–brain barrier using nanomaterials
A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis,
brain tumors, and strokes is the blood–brain barrier (BBB). The BBB prevents the passage of …
brain tumors, and strokes is the blood–brain barrier (BBB). The BBB prevents the passage of …
Affinity-driven design of cargo-switching nanoparticles to leverage a cholesterol-rich microenvironment for atherosclerosis therapy
Atherosclerotic plaques exhibit high deposition of cholesterol and macrophages. These are
not only the main components of the plaques but also key inflammation-triggering sources …
not only the main components of the plaques but also key inflammation-triggering sources …
Cyclodextrins applied to the treatment of lysosomal storage disorders
Y Ishitsuka, T Irie, M Matsuo - Advanced Drug Delivery Reviews, 2022 - Elsevier
Cyclodextrin (CD), a cyclic oligosaccharide, is a pharmaceutical additive that improves the
solubility of hydrophobic compounds. Recent research has focused on the potential active …
solubility of hydrophobic compounds. Recent research has focused on the potential active …
Polymer-based drug delivery systems under investigation for enzyme replacement and other therapies of lysosomal storage disorders
Lysosomes play a central role in cellular homeostasis and alterations in this compartment
associate with many diseases. The most studied example is that of lysosomal storage …
associate with many diseases. The most studied example is that of lysosomal storage …
Graphene oxide induces p62/SQSTM-dependent apoptosis through the impairment of autophagic flux and lysosomal dysfunction in PC12 cells
X Feng, L Chen, W Guo, Y Zhang, X Lai, L Shao, Y Li - Acta biomaterialia, 2018 - Elsevier
Graphene oxide (GO), as a two-dimensional carbon nanosheet, has been extensively
studied for potential biomedical applications due to its notable properties. Although a …
studied for potential biomedical applications due to its notable properties. Although a …
Lipid-based pulmonary delivery system: a review and future considerations of formulation strategies and limitations
CL Ngan, AA Asmawi - Drug delivery and translational research, 2018 - Springer
Inhalation therapy of lipid-based carriers has great potential in direct target towards the root
of respiratory diseases, which make them superior over other drug deliveries. With the …
of respiratory diseases, which make them superior over other drug deliveries. With the …
Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation
Background Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause
of mortality worldwide. Cholesterol crystals (CCs) induce inflammation in atherosclerosis …
of mortality worldwide. Cholesterol crystals (CCs) induce inflammation in atherosclerosis …
The complexity of a monogenic neurodegenerative disease: More than two decades of therapeutic driven research into Niemann-Pick type C disease
N Hammond, AB Munkacsi, SL Sturley - Biochimica et Biophysica Acta …, 2019 - Elsevier
Abstract Niemann-Pick type C (NP-C) disease is a rare and fatal neurodegenerative disease
typified by aberrations in intracellular lipid transport. Cholesterol and other lipids accumulate …
typified by aberrations in intracellular lipid transport. Cholesterol and other lipids accumulate …