Pharmacogenes (PGx-genes): current understanding and future directions

P Katara, A Yadav - Gene, 2019 - Elsevier
Individual specific variable drug response against similar drugs raises a significant
challenge for the effective and safe treatment of many human diseases. Pharmacogenomics …

PGxKnow: a pharmacogenomics educational HoloLens application of augmented reality and artificial intelligence

D Roosan, J Chok, A Baskys, MR Roosan - Pharmacogenomics, 2022 - Taylor & Francis
Aim: To develop and assess an augmented reality tool for pharmacogenomics (PGx)
education based on artificial intelligence. Materials & methods: A HoloLens application was …

Further Investigation of the Role of ACYP2 and WFS1 Pharmacogenomic Variants in the Development of Cisplatin-Induced Ototoxicity in Testicular Cancer Patients

BI Drögemöller, B Brooks, C Critchley, JG Monzon… - Clinical Cancer …, 2018 - AACR
Purpose: Adverse drug reactions such as ototoxicity, which occurs in approximately one-fifth
of adult patients who receive cisplatin treatment, can incur large socioeconomic burdens on …

Population-scale genomics—Enabling precision public health

A Sivadas, V Scaria - Advances in genetics, 2019 - Elsevier
The current excitement for affordable genomics technologies and national precision
medicine initiatives marks a turning point in worldwide healthcare practices. The last decade …

PharmVIP: A web-based tool for pharmacogenomic variant analysis and interpretation

J Piriyapongsa, C Sukritha, P Kaewprommal… - Journal of Personalized …, 2021 - mdpi.com
The increasing availability of next generation sequencing (NGS) for personal genomics
could promote pharmacogenomics (PGx) discovery and application. However, current tools …

Prediction of adverse drug reactions due to genetic predisposition using deep neural networks

B Dafniet, O Taboureau - Molecular Informatics, 2024 - Wiley Online Library
Drug development is a long and costly process, often limited by the toxicity and adverse
drug reactions (ADRs) caused by drug candidates. Even on the market, some drugs can …

ePGA: a web-based information system for translational pharmacogenomics

K Lakiotaki, E Kartsaki, A Kanterakis, T Katsila… - PLoS …, 2016 - journals.plos.org
One of the challenges that arise from the advent of personal genomics services is to
efficiently couple individual data with state of the art Pharmacogenomics (PGx) knowledge …

g-Nomic: A new pharmacogenetics interpretation software

A Sabater, CJ Ciudad, M Cendros… - Pharmacogenomics …, 2019 - Taylor & Francis
We present g-Nomic, a pharmacogenetics interpretation software that analyzes globally a
prescribed medication taking into account the personal background genetics, drug–drug …

Systematic Review and Meta‐analysis of the Influence of Genetic Variation on Ototoxicity in Platinum‐Based Chemotherapy

DZ Hong, TCC Ong, DP Timbadia… - … –Head and Neck …, 2023 - Wiley Online Library
Objective The objective of this meta‐analysis is to evaluate the impact of genetic
polymorphisms on platinum‐based chemotherapy (PBC)‐induced ototoxicity. Data Sources …

Pharmacogenetic variation in over 100 genes in patients receiving acenocumarol

V Gonzalez-Covarrubias, J Urena-Carrion… - Frontiers in …, 2017 - frontiersin.org
Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred
form. It is well known that despite its efficacy, coumarins show a high variability for dose …