Pharmacogenes (PGx-genes): current understanding and future directions
Individual specific variable drug response against similar drugs raises a significant
challenge for the effective and safe treatment of many human diseases. Pharmacogenomics …
challenge for the effective and safe treatment of many human diseases. Pharmacogenomics …
PGxKnow: a pharmacogenomics educational HoloLens application of augmented reality and artificial intelligence
Aim: To develop and assess an augmented reality tool for pharmacogenomics (PGx)
education based on artificial intelligence. Materials & methods: A HoloLens application was …
education based on artificial intelligence. Materials & methods: A HoloLens application was …
Further Investigation of the Role of ACYP2 and WFS1 Pharmacogenomic Variants in the Development of Cisplatin-Induced Ototoxicity in Testicular Cancer Patients
BI Drögemöller, B Brooks, C Critchley, JG Monzon… - Clinical Cancer …, 2018 - AACR
Purpose: Adverse drug reactions such as ototoxicity, which occurs in approximately one-fifth
of adult patients who receive cisplatin treatment, can incur large socioeconomic burdens on …
of adult patients who receive cisplatin treatment, can incur large socioeconomic burdens on …
Population-scale genomics—Enabling precision public health
The current excitement for affordable genomics technologies and national precision
medicine initiatives marks a turning point in worldwide healthcare practices. The last decade …
medicine initiatives marks a turning point in worldwide healthcare practices. The last decade …
PharmVIP: A web-based tool for pharmacogenomic variant analysis and interpretation
J Piriyapongsa, C Sukritha, P Kaewprommal… - Journal of Personalized …, 2021 - mdpi.com
The increasing availability of next generation sequencing (NGS) for personal genomics
could promote pharmacogenomics (PGx) discovery and application. However, current tools …
could promote pharmacogenomics (PGx) discovery and application. However, current tools …
Prediction of adverse drug reactions due to genetic predisposition using deep neural networks
B Dafniet, O Taboureau - Molecular Informatics, 2024 - Wiley Online Library
Drug development is a long and costly process, often limited by the toxicity and adverse
drug reactions (ADRs) caused by drug candidates. Even on the market, some drugs can …
drug reactions (ADRs) caused by drug candidates. Even on the market, some drugs can …
ePGA: a web-based information system for translational pharmacogenomics
One of the challenges that arise from the advent of personal genomics services is to
efficiently couple individual data with state of the art Pharmacogenomics (PGx) knowledge …
efficiently couple individual data with state of the art Pharmacogenomics (PGx) knowledge …
g-Nomic: A new pharmacogenetics interpretation software
A Sabater, CJ Ciudad, M Cendros… - Pharmacogenomics …, 2019 - Taylor & Francis
We present g-Nomic, a pharmacogenetics interpretation software that analyzes globally a
prescribed medication taking into account the personal background genetics, drug–drug …
prescribed medication taking into account the personal background genetics, drug–drug …
Systematic Review and Meta‐analysis of the Influence of Genetic Variation on Ototoxicity in Platinum‐Based Chemotherapy
DZ Hong, TCC Ong, DP Timbadia… - … –Head and Neck …, 2023 - Wiley Online Library
Objective The objective of this meta‐analysis is to evaluate the impact of genetic
polymorphisms on platinum‐based chemotherapy (PBC)‐induced ototoxicity. Data Sources …
polymorphisms on platinum‐based chemotherapy (PBC)‐induced ototoxicity. Data Sources …
Pharmacogenetic variation in over 100 genes in patients receiving acenocumarol
V Gonzalez-Covarrubias, J Urena-Carrion… - Frontiers in …, 2017 - frontiersin.org
Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred
form. It is well known that despite its efficacy, coumarins show a high variability for dose …
form. It is well known that despite its efficacy, coumarins show a high variability for dose …