During the past decade, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. Although the origin and plasticity of these cells remain controversial, tumour …

Answer questions and earn CME/CNE Pancreatic cancer is currently one of the deadliest of
the solid malignancies. However, surgery to resect neoplasms of the pancreas is safer and …

The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can
be either applied externally by the surrounding normal tissue or induced by the tumor itself …

Background Trametinib, an oral mitogen/extracellular signal-related kinase (MEK) 1/2
inhibitor, holds promise for malignancies with rat sarcoma (RAS) mutations, like pancreas …

Pancreatic cancer has one of the poorest prognoses of all malignancies, with little
improvement in clinical outcome over the past 40 years. Pancreatic ductal adenocarcinoma …

Pancreatic cancer is a leading cause of cancer mortality and the incidence of this disease is
expected to continue increasing. While patients with pancreatic cancer have traditionally …

Pancreatic ductal adenocarcinoma is one of the most aggressive cancers, and surgical
resection is a requirement for a potential cure. However, the majority of patients are …

Background Pancreatic cancer (PC) is a highly lethal disease with few effective treatment
options. Over the past few decades, many anti‐cancer therapies have been tested in the …

ABSTRACT Background The NHS Cancer Drugs Fund (CDF) was established in 2010 to
reduce delays and improve access to cancer drugs, including those that had been …

Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant stromal
response also known as a desmoplastic reaction. Pancreatic Stellate Cells have been …