Der" Sewald/Jakubke" ist und bleibt das einzige moderne, auf dem neuesten
wissenschaftlichen Stand gehaltene fortgeschrittene Lehrbuch der Peptid-Biochemie! Auch …

With the decline in productivity of drug‐development efforts, novel approaches to rational
drug design are being introduced and developed. Naturally occurring and synthetic peptides …

Although not complying with Lipinski's rule, peptides are to an increasing extent being
developed into new active pharmaceutical ingredients. This is mainly due to novel …

Gene delivery systems based on the β-cyclodextrin scaffold have been synthesized by
combining the copper (I)-catalyzed azide-alkyne coupling (“click chemistry”) and an efficient …

Protein− protein interactions (PPIs) represent a significant portion of functionally relevant
biological interactions, and therefore potential therapeutic targets. Small molecules were …

Backbone-cyclized peptides and peptidomimetics integrate the biological activity and
pharmacological features necessary for successful research tools and therapeutics. In …

Two homochiral building blocks featuring a protected thiol, an alkene and a H-bond
recognition unit (phenol or phosphine oxide) have been prepared. Iterative photochemical …

Scanning tunneling microscope break junction measurements are used to examine how the
molecular conductance of nucleic acids depends on the composition of their backbone and …

The insulin-like growth factors (IGF) and their receptors play pivotal roles in cellular
signaling transduction and thus regulate cell growth, differentiation, apoptosis …

A general strategy is introduced for the efficient synthetic access of disulfide linked artificial
macrocycles via a Ugi four-component reaction (U4CR) followed by oxidative cyclization …