Human brain organogenesis: Toward a cellular understanding of development and disease
The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
Developmental mechanisms underlying the evolution of human cortical circuits
P Vanderhaeghen, F Polleux - Nature Reviews Neuroscience, 2023 - nature.com
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
Comparative cellular analysis of motor cortex in human, marmoset and mouse
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …
Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex
Recent advances in multi-electrode array technology have made it possible to monitor large
neuronal ensembles at cellular resolution in animal models. In humans, however, current …
neuronal ensembles at cellular resolution in animal models. In humans, however, current …
Connectomic comparison of mouse and human cortex
The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex
of a mouse, but the possible differences in synaptic circuits between these species are still …
of a mouse, but the possible differences in synaptic circuits between these species are still …
Conserved cell types with divergent features in human versus mouse cortex
Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA …
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA …
[HTML][HTML] Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution
Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …
Dendritic action potentials and computation in human layer 2/3 cortical neurons
A Gidon, TA Zolnik, P Fidzinski, F Bolduan, A Papoutsi… - Science, 2020 - science.org
The active electrical properties of dendrites shape neuronal input and output and are
fundamental to brain function. However, our knowledge of active dendrites has been almost …
fundamental to brain function. However, our knowledge of active dendrites has been almost …
[HTML][HTML] Evolution of cortical neurons supporting human cognition
Human cognitive abilities are generally thought to arise from cortical expansion over the
course of human brain evolution. In addition to increased neuron numbers, this cortical …
course of human brain evolution. In addition to increased neuron numbers, this cortical …
Development and functional diversification of cortical interneurons
In the cerebral cortex, GABAergic interneurons have evolved as a highly heterogeneous
collection of cell types that are characterized by their unique spatial and temporal …
collection of cell types that are characterized by their unique spatial and temporal …