Human brain organogenesis: Toward a cellular understanding of development and disease

KW Kelley, SP Pașca - Cell, 2022 - cell.com
The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …

Developmental mechanisms underlying the evolution of human cortical circuits

P Vanderhaeghen, F Polleux - Nature Reviews Neuroscience, 2023 - nature.com
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

Comparative cellular analysis of motor cortex in human, marmoset and mouse

TE Bakken, NL Jorstad, Q Hu, BB Lake, W Tian… - Nature, 2021 - nature.com
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …

Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex

AC Paulk, Y Kfir, AR Khanna, ML Mustroph… - Nature …, 2022 - nature.com
Recent advances in multi-electrode array technology have made it possible to monitor large
neuronal ensembles at cellular resolution in animal models. In humans, however, current …

Connectomic comparison of mouse and human cortex

S Loomba, J Straehle, V Gangadharan, N Heike… - Science, 2022 - science.org
The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex
of a mouse, but the possible differences in synaptic circuits between these species are still …

Conserved cell types with divergent features in human versus mouse cortex

RD Hodge, TE Bakken, JA Miller, KA Smith, ER Barkan… - Nature, 2019 - nature.com
Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA …

[HTML][HTML] Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution

CA Herring, RK Simmons, S Freytag, D Poppe… - Cell, 2022 - cell.com
Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …

Dendritic action potentials and computation in human layer 2/3 cortical neurons

A Gidon, TA Zolnik, P Fidzinski, F Bolduan, A Papoutsi… - Science, 2020 - science.org
The active electrical properties of dendrites shape neuronal input and output and are
fundamental to brain function. However, our knowledge of active dendrites has been almost …

[HTML][HTML] Evolution of cortical neurons supporting human cognition

AA Galakhova, S Hunt, R Wilbers, DB Heyer… - Trends in cognitive …, 2022 - cell.com
Human cognitive abilities are generally thought to arise from cortical expansion over the
course of human brain evolution. In addition to increased neuron numbers, this cortical …

Development and functional diversification of cortical interneurons

L Lim, D Mi, A Llorca, O Marín - Neuron, 2018 - cell.com
In the cerebral cortex, GABAergic interneurons have evolved as a highly heterogeneous
collection of cell types that are characterized by their unique spatial and temporal …