Recent advances in the characterization of the archaeal DNA replication system together
with comparative genomic analysis have led to the identification of several previously …

Genetic techniques for the Archaea have undergone a rapid expansion in complexity,
resulting in increased exploration of the role of Archaea in the environment and detailed …

A comprehensive whole-genome analysis of gene function by transposon mutagenesis and
deep sequencing methodology has been implemented successfully in a representative of …

DNA interstrand crosslinks (ICLs) are highly toxic lesions that stall the replication fork to
initiate the repair process during the S phase of vertebrates. Proteins involved in Fanconi …

Background Prokaryotes have relatively small genomes, densely-packed with protein-
encoding sequences. RNA sequencing has, however, revealed surprisingly complex …

Background In eukaryotes, the CMG (CDC45, MCM, GINS) complex containing the
replicative helicase MCM is a key player in DNA replication. Archaeal homologs of the …

The archaeal machinery responsible for DNA replication is largely homologous to that of
eukaryotes and is clearly distinct from its bacterial counterpart. Moreover, it shows high …

The tree of life shows the relationship between all organisms based on their common
ancestry. Until 1977, it comprised two major branches: prokaryotes and eukaryotes. Work by …

This section provides an overview of the genetic systems developed in the Archaea. Genetic
manipulation is possible in many members of the halophiles, methanogens, Sulfolobus, and …

DNA replication is essential for all life forms. Although the process is fundamentally
conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic …